70485
萘酚AS-E磷酸盐
suitable for histology
别名:
KG-501
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关于此项目
经验公式（希尔记法）:
C17H13ClNO5P
化学文摘社编号:
分子量:
377.72
Beilstein:
6664478
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.83
方案
≥80% (HPLC)
质量水平
表单
powder
应用
histology
储存温度
2-8°C
SMILES字符串
OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
InChI
1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
InChI key
RQAQWBFHPMSXKR-UHFFFAOYSA-N
应用
Naphthol AS-E磷酸盐已被用作cAMP反应元件结合蛋白（CREB）的抑制剂，以溶解于二甲基亚砜（DMSO）中作为研究中的储存溶液，来验证制癌蛋白M（OSM）可能会赋予针对3-硝基丙酸（3-NP）的神经元抗性的假设。
生化/生理作用
Naphthol AS-E磷酸盐/KG501是一种小分子拮抗剂，具有阻止cAMP反应元件结合蛋白（CREB）通路的能力。它还可在体外干扰Myb-KIX的相互作用并阻断Myb在体内的作用。
其他说明
碱性磷酸酶的组织化学底物，KG-501可通过干扰CREB的KID结构域和CBP（CREB结合蛋白）的KIX结构域之间这一经典的激活剂-共激活因子互作结合，来阻断CREB（cAMP反应元件结合蛋白）依赖性靶基因转录（Ki 10 microM）的cAMP-诱导。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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Proceedings of the National Academy of Sciences of the United States of America, 113(4), 1032-1037 (2016-01-13)
The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signaling through B-lymphocyte receptors, including CD40, BAFF receptor, and Toll-like receptors, and also plays a critical role inhibiting B-cell homoeostatic survival. Consistent with these findings, loss-of-function human TRAF3 mutations are common
Cody McGrath et al.
Frontiers in endocrinology, 12, 782194-782194 (2022-02-12)
Exercise, typically beneficial for skeletal health, has not yet been studied in lipodystrophy, a condition characterized by paucity of white adipose tissue, with eventual diabetes, and steatosis. We applied a mouse model of global deficiency of Bscl2 (SEIPIN), required for
Phosphates of the naphthol AS series in the quantitative determination of alkaline and acid phosphatase activities in situ studied in polyacrylamide membrane model systems and by cytospectrophotometry
Lojda, Z., et al.
Histochemistry and Cell Biology, 11, 13-32 (1967)
Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300
Uttarkar S, et al.
Molecular Cancer Therapeutics, molcanther-molcan0662 (2015)
Kaori Kubota et al.
Frontiers in pharmacology, 8, 850-850 (2017-12-07)
Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we
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