Merck
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文件

72779

Sigma-Aldrich

三氯生

97.0-103.0% (active substance, GC)

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别名:
三氯苯氧氯酚, 5-氯-2-（2,4-二氯苯氧基）苯酚, 氯苯酚
经验公式（希尔记法）:
C12H7Cl3O2
CAS号:
3380-34-5
分子量:
289.54
Beilstein:
2057142
EC 号:
222-182-2
MDL编号:
MFCD00800992
PubChem化学物质编号:
57652433
NACRES:
NA.85

生物来源

synthetic

质量水平

200

检测方案

97.0-103.0% (active substance, GC)

形式

powder or crystals

杂质

≤0.1% Water (Karl Fischer)

颜色

white

mp

55-59 °C

溶解性

1 M NaOH: 5% at 25 °C, faintly turbid to clear (colorless solution)

抗生素抗菌谱

fungi

作用机制

enzyme | inhibits

SMILES string

Oc1cc(Cl)ccc1Oc2ccc(Cl)cc2Cl

InChI

1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H

InChI key

XEFQLINVKFYRCS-UHFFFAOYSA-N

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相关类别

一般描述

化学结构式：二苯醚衍生物

应用

它是一种用于耶尔森菌（一种可能污染动物源食品的人类病原体）的头孢磺啶-氯苯酚-新生霉素选择培养基的组分。由于其抗原性低，irgasan 也是许多抗菌消费品的组成部分。

生化/生理作用

Irgasan 是一种广谱抗菌药物。它是细菌和 疟原虫中 II 类型脂肪酸合成酶 (FAS-II) 的烯酰-ACP（酰基载体蛋白）还原酶成分的抑制剂 。它也抑制哺乳动物脂肪酸合成酶 (FASN)，并可能具有抗癌活性。

其他说明

将容器紧紧地封闭在干燥通风良好的地方。保存在干燥的地方。

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险声明

H315 - H319 - H410

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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货号
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包装规格/数量

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部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。

索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is Product 72779, Irgasan, soluble in?

    Per the chemicals encyclopedia published by the Royal Society of Chemistry, 12th edition, Entry# 9790, Irgasan is not soluble in water, but it is readily soluble in alkaline solutions and many organic solvents.

  4. What are other names besides Irgasan that Product 72779 may be referred to?

    Irgasan may also be referred to as Triclosan and 5-Chloro-2-(2,4-dichlorophenoxy)phenol.

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Kathleen Dittmann et al.
Antimicrobial resistance and infection control, 8, 122-122 (2019-08-02)
Recent publications have raised concerns of reduced susceptibilities of clinical bacterial isolates towards biocides. This study presents a comparative investigation of the susceptibility of livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA), hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA) to the commonly used
Cale T Anger et al.
Environmental science & technology, 47(4), 1833-1843 (2013-01-17)
When discharged into surface waters via wastewater effluents, triclosan, the antimicrobial agent in handsoaps, and chlorinated triclosan derivatives (CTDs, formed during disinfection with chlorine) react photochemically to form polychlorinated dibenzo-p-dioxins. To evaluate the historical exposure of waters to these compounds
Markus K Diener et al.
Lancet (London, England), 384(9938), 142-152 (2014-04-11)
Postoperative surgical site infections are one of the most frequent complications after open abdominal surgery, and triclosan-coated sutures were developed to reduce their occurrence. The aim of the PROUD trial was to obtain reliable data for the effectiveness of triclosan-coated
R M Davies et al.
Journal of clinical periodontology, 31(12), 1029-1033 (2004-11-25)
To compare the effectiveness of triclosan/copolymer and fluoride dentifrices in improving plaque control and gingival health. We searched the Cochrane Controlled Trials Register, MEDLINE (1986 to March 2003) and EMBASE (1986 to March 2003). Personal files and the reference lists
Anthony Blinkhorn et al.
British dental journal, 207(3), 117-125 (2009-08-08)
Dental caries and periodontal disease are the most common oral conditions experienced by adults today. The treatment of these diseases by the dental team can only be performed when patients attend dental practices. There is recognition that the preventive measures
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