73677
4-硝基苯基 β-D-葡糖苷酸
β-glucuronidase substrate, chromogenic, ≥99.0% (TLC), powder or crystals, suitable as substrate for β-glucuronidase test
别名:
4-硝基苯基-β-D-吡喃葡萄糖醛酸, PNPG
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关于此项目
经验公式（希尔记法）:
C12H13NO9
化学文摘社编号:
分子量:
315.23
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
233-753-0
MDL number:
Beilstein/REAXYS Number:
1438576
产品名称
4-硝基苯基 β-D-葡糖苷酸, ≥99.0% (TLC)
InChI key
QSUILVWOWLUOEU-GOVZDWNOSA-N
InChI
1S/C12H13NO9/c14-7-8(15)10(11(17)18)22-12(9(7)16)21-6-3-1-5(2-4-6)13(19)20/h1-4,7-10,12,14-16H,(H,17,18)/t7-,8-,9+,10-,12+/m0/s1
SMILES string
O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H]1O)C(O)=O)Oc2ccc(cc2)[N+]([O-])=O
assay
≥99.0% (TLC)
form
powder or crystals
optical activity
[α]20/D −102±3°, c = 1% in ethanol
impurities
≤0.05% free 4-nitrophenol
≤7% water
solubility
H2O: 0.1 g/mL, clear, faintly yellow
suitability
suitable as substrate for β-glucuronidase test
storage temp.
−20°C
Quality Level
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Application
4-硝基苯基β-D-葡萄糖醛酸苷用于测定尿液样本中β-葡萄糖醛酸苷酶的活性，盲肠内容物消化物细菌和牛肝中β-葡萄糖醛酸苷酶的活性。 也用来研究苦味叶下珠提取物对β-葡萄糖醛酸苷酶的抑制作用。
General description
用于 β-葡萄糖醛酸酶（GUS）基因检测的显色底物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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El-Arab AME, et al.
BMC Complementary and Alternative Medicine, 6(1), 6-6 (2006)
Effect of tobacco smoking on albumin concentration and beta-glucuronidase activity in urine of smelters
Bizonn A, et al.
Przegla?d Lekarski, 71(11), 581-584 (2014)
Synthesis of Glycaro-1, 5-lactams and Tetrahydrotetrazolopyridine-5-carboxylates: Inhibitors of beta-D-Glucuronidase and alpha-L-Iduronidase
Pabba J, et al.
Helvetica Chimica Acta, 89(4), 635-666 (2006)
C Y Ng et al.
The Journal of pharmacology and experimental therapeutics, 295(2), 830-835 (2000-10-25)
Congestive heart failure has been shown to affect oxidative drug metabolism, however, there has been little study of its effects on drug conjugation. Using the isolated perfused livers from rats with right ventricular failure (RVF) due to pulmonary artery constriction
E E Guibert et al.
Experientia, 39(5), 527-528 (1983-05-15)
The effect of spironolactone (SP) on p-nitrophenol (PNP) glucuronidation was studied in isolated rat hepatocytes with appropriate viability conditions. A significant increase of protein concentration and PNP glucuronidation was found in the hepatocytes from SP-treated rats. Increased enzyme activity apparently
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