76157
(4R)-4-羟基-L-谷氨酸
≥98.0% (TLC)
别名:
erythro-(4R)-4-Hydroxy-L-glutamic acid, H-(2S,4R)-γ-Hydroxy-Glu-OH
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关于此项目
经验公式（希尔记法）:
C5H9NO5
化学文摘社编号:
分子量:
163.13
NACRES:
NA.28
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
1725871
产品名称
(4R)-4-羟基-L-谷氨酸, ≥98.0% (TLC)
Quality Level
assay
≥98.0% (TLC)
form
powder
optical activity
[α]/D 20.5±1.5°, c = 1 in H2O
color
white
mp
171 °C
storage temp.
−20°C
SMILES string
N[C@@H](C[C@@H](O)C(O)=O)C(O)=O
InChI
1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
InChI key
HBDWQSHEVMSFGY-STHAYSLISA-N
Biochem/physiol Actions
(4R)-4-Hydroxy-L-glutamic acid or (2S,4R)-4-hydroxyglutamate was shown to activate the metabotropic glutamate receptors, mGlu1a, mGlu2, and mGlu8a in a dose-dependent manner.
Substrate for aminotransferase; pharmacological characterization at human glutamate transporter subtypes 1-3; for studying structure-activity relationships (SAR) for ionotropic and metabotropic glutamate receptors.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver.
A GOLDSTONE et al.
The Journal of biological chemistry, 237, 3476-3485 (1962-11-01)
Lennart Bunch et al.
ChemMedChem, 4(11), 1925-1929 (2009-09-05)
Subtype-selective ligands are of great interest to the scientific community, as they provide a tool for investigating the function of one receptor or transporter subtype when functioning in its native environment. Several 4-substituted (S)-glutamate (Glu) analogues were synthesized, and altogether
A S Bessis et al.
Bioorganic & medicinal chemistry letters, 11(12), 1569-1572 (2001-06-20)
The (2S,4R)- and (2S,4S)-4-hydroxyglutamates activate cloned mGlu(1a), mGlu(2), and mGlu(8a) receptors with different potencies. Best results were obtained with the (2S,4S) isomer being almost as potent as glutamate on mGlu(1a)R and mGlu(8a)R. Data are interpreted on the basis of the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 76157-50MG | 04061832720265 |
| 76157-10MG | 04061832720258 |