79849
(±)-甲羟戊酸 5-磷酸盐 锂盐 水合物
95% (TLC)
别名:
(±)-MVAP-Li, 外消旋-5-磷甲羟戊酸 锂盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C6H13O7P · xLi+ · yH2O
分子量:
228.14 (free acid basis)
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
产品名称
(±)-甲羟戊酸 5-磷酸盐 锂盐 水合物, 95% (TLC)
SMILES string
OC(CC(C)(O)CCOP(O)(O)=O)=O.[H]O[H].[Li+]
InChI
1S/C6H13O7P.3Li.H2O/c1-6(9,4-5(7)8)2-3-13-14(10,11)12;;;;/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12);;;;1H2/q;3*+1;/p-3
InChI key
VYTYNAKRCDFACM-UHFFFAOYSA-K
assay
95% (TLC)
form
powder or crystals
relevant disease(s)
Alzheimer′s disease; autoimmune diseases
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
甲羟戊酸途径的代谢产物，在甾醇、多萜醇、血红素和泛醌的生物合成中起关键作用。对肿瘤学、自身免疫性疾病、动脉粥样硬化和阿尔茨海默病等疾病领域的研究以及甲羟戊酸激酶的遗传缺陷感兴趣。
Packaging
无底玻璃瓶。内容物在插入式融锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
D N Skilleter et al.
The Biochemical journal, 124(2), 407-417 (1971-09-01)
1. Phosphomevalonate kinase and 5-pyrophosphomevalonate decarboxylase have been purified from the freeze-dried latex serum of the commercial rubber tree Hevea brasiliensis. 2. The phosphomevalonate kinase was acid- and heat-labile and required the presence of a thiol to maintain activity. 3.
Li Gong et al.
Cell death & disease, 10(4), 327-327 (2019-04-13)
The mevalonate pathway is known for the synthesis of cholesterol, but recent studies have reported that it also controls Hippo signaling, which is critical for the regulation of organ size and tumorigenesis. Here, we discover that the suppression of the
Andrew L Olson et al.
Journal of the American Chemical Society, 132(7), 2102-2103 (2010-02-02)
Phosphomevalonate kinase (PMK) catalyzes phosphoryl transfer from adenosine triphosphate (ATP) to mevalonate 5-phosphate (M5P) on the pathway for synthesizing cholesterol and other isoprenoids. To permit this reaction, its substrates must be brought proximal, which would result in a significant and
John L Andreassi et al.
Biochemistry, 48(27), 6461-6468 (2009-06-03)
The galacto-, homoserine-, mevalonate-, phosphomevalonate-kinase (GHMP) superfamily encompases a wide-range of protein function. Three members of the family (mevalonate kinase, phosphomevalonate kinase, and diphosphomevalonate decarboxylase) comprise the mevalonate pathway found in S. pneumoniae and other organisms. We have determined the
Inhibition of hepatic cholesterol biosynthesis by 3,5-dihydroxy-3,4,4-trimethylvaleric acid and its site of action.
F H Hulcher
Archives of biochemistry and biophysics, 146(2), 422-427 (1971-10-01)
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