82890
吡哆胺-5′-磷酸盐
≥98.0% (HPLC)
别名:
4-氨甲基-5-羟基-6-甲基-3-吡啶甲基磷酸盐
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关于此项目
经验公式（希尔记法）:
C8H13N2O5P
化学文摘社编号:
分子量:
248.17
UNSPSC Code:
12352116
NACRES:
NA.79
PubChem Substance ID:
EC Number:
208-471-6
Beilstein/REAXYS Number:
233653
MDL number:
InChI key
ZMJGSOSNSPKHNH-UHFFFAOYSA-N
InChI
1S/C8H13N2O5P/c1-5-8(11)7(2-9)6(3-10-5)4-15-16(12,13)14/h3,11H,2,4,9H2,1H3,(H2,12,13,14)
SMILES string
Cc1ncc(COP(O)(O)=O)c(CN)c1O
assay
≥98.0% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
faint beige to light beige, white to light yellow
Quality Level
General description
吡哆胺是维生素B6的一种衍生物。吡哆胺是一种水溶性维生素。维生素B6衍生物包含一个核心吡啶环。吡哆胺在吡啶的′4′位上含有一个氨甲基。
Application
5-磷酸吡哆胺适合于：
- 胞苷二磷酸-4-酮基-3,6-二脱氧葡萄糖的酶催化合成
- 作为5-磷酸吡哆胺磷酸酶活性测定的底物
- 作为表征5-吡i磷酸吡哆醇氧化酶的底物
- 用于NaBH4还原的糖原磷酸化酶b性质的吸收和荧光研究，以探测PMP残基的微环境
- 作为表征各种物种和组织中磷酸吡哆胺转氨酶的底物
Biochem/physiol Actions
以 (S)-α-甲基苄胺 (MBA) 为胺供体采用丙酮酸转氨酶生物催化剂可以将5′-磷酸吡哆醛转化为5′-磷酸吡哆胺。以黄素单核苷酸（FMN）为直接电子受体，氧为最终电子受体，通过大肠杆菌5′-磷酸吡哆醇（吡哆胺）氧化酶可以将5′-磷酸吡哆醇和5′-磷酸吡哆胺氧化成5′-磷酸吡哆醛（PLP）。
已通过吸收和荧光光谱研究评价了处于单重激发态的5′-磷酸吡哆胺的 p K （5-磷酸吡哆胺， PAMP ）。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The kinetic properties of pyridoxamine (pyridoxine)-5'-phosphate oxidase have been studied using the physiological substrates pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) at 25 degrees C and pH 8.0. Under steady-state conditions with different concentrations of PNP and O2, a series
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Journal of biochemistry, 116(5), 1001-1012 (1994-11-01)
The three-dimensional structures of pyridoxamine 5'-phosphate-type aspartate aminotransferase from Escherichia coli and its complexes with maleate and glutarate have been determined by X-ray crystallography at 2.2, 2.1, and 2.7 A resolution, respectively. The enzyme is a dimeric form comprising two
Sonia Herrero et al.
Plant molecular biology, 76(1-2), 157-169 (2011-05-03)
Vitamin B6 (pyridoxal phosphate) is an essential cofactor in enzymatic reactions involved in numerous cellular processes and also plays a role in oxidative stress responses. In plants, the pathway for de novo synthesis of pyridoxal phosphate has been well characterized
Synthesis of pyridoxamine 5?-phosphate using an MBA: pyruvate transaminase as biocatalyst.
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Journal of Molecular Catalysis. B, Enzymatic, 59, 279-285 (2009)
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