85590
精胺
≥99.0% (GC)
别名:
N,N′-双(3-氨基丙基)-1,4-丁二胺, 精素, 肌胺, 肝胺
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关于此项目
线性分子式:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
化学文摘社编号:
分子量:
202.34
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-754-2
Beilstein/REAXYS Number:
1750791
MDL number:
产品名称
精胺, ≥99.0% (GC)
InChI key
PFNFFQXMRSDOHW-UHFFFAOYSA-N
InChI
1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
SMILES string
[H]N(CCCN)CCCCN([H])CCCN
biological source
microbial
synthetic
assay
≥99.0% (GC)
form
crystalline (chunks)
impurities
≤0.5% spermidine
bp
150 °C/5 mmHg (lit.)
mp
28-30 (lit.)
solubility
water: 0.05 g/mL, clear, colorless
anion traces
carbonate (CO32-): ≤5000 mg/kg
storage temp.
2-8°C
Quality Level
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Application
精胺是一种多阳离子生物多胺，来源于亚精胺，可作为补充剂或调节剂广泛应用于生物领域。用作负离子模式下唾液酸化聚糖 MALDI-MS 的 DHB 共基质。
Biochem/physiol Actions
多胺位点混合型 NMDA 受体激动剂/拮抗剂。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。
多胺位点混合型 NMDA 谷氨酸受体激动剂/拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Y Mechref et al.
Journal of the American Society for Mass Spectrometry, 9(12), 1293-1302 (1998-12-03)
Negative-ion matrix-assisted laser desorption/ionization mass spectra of sialyated glycoconjugates were acquired employing 2,5-dihydroxybenzoic acid (DHB) in conjunction with spermine as a co-matrix. The addition of spermine to DHB permitted an improved crystal formation as well as a higher analyte solubility.
Nicole K L Lee et al.
Journal of cellular physiology, 226(6), 1453-1460 (2011-03-18)
The naturally occurring polyamines, spermidine, spermine, and their precursor putrescine, play indispensible roles in both prokaryotic and eukaryotic cells, from basic DNA synthesis to regulation of cell proliferation and differentiation. The rate-limiting polyamine biosynthetic enzymes, ornithine decarboxylase (ODC) and S-adenosylmethionine
H Hosseinkhani et al.
Gene therapy, 11(2), 194-203 (2004-01-09)
Dextran-spermine cationic polysaccharide was prepared by means of reductive amination between oxidized dextran and the natural oligoamine spermine. The formed Schiff-base imine-based conjugate was reduced with borohydride to obtain the stable amine-based conjugate. The transfection efficiency of the synthetic dextran-spermine
Brian R Lee et al.
Nature neuroscience, 16(11), 1644-1651 (2013-10-01)
In rat models of drug relapse and craving, cue-induced cocaine seeking progressively increases after withdrawal from the drug. This 'incubation of cocaine craving' is partially mediated by time-dependent adaptations at glutamatergic synapses in nucleus accumbens (NAc). However, the circuit-level adaptations
Lydia P P Liew et al.
Bioorganic & medicinal chemistry letters, 23(2), 452-454 (2012-12-26)
Screening of synthesized and isolated marine natural products for in vitro activity against four parasitic protozoa has identified the ascidian metabolite 1,14-sperminedihomovanillamide (orthidine F, 1) as being a non-toxic, moderate growth inhibitor of Plasmodium falciparum (IC(50) 0.89 μM). Preliminary structure-activity
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