88185
四唑 溶液
~0.45 M in acetonitrile, solution, suitable for DNA synthesis, filtered through a 1 μm filter
别名:
1H-Tetrazole
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关于此项目
经验公式（希尔记法）:
CH2N4
化学文摘社编号:
分子量:
70.05
Beilstein:
105799
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.21
产品名称
四唑 溶液, suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile
表单
liquid
质量水平
质量
filtered through a 1 μm filter
浓度
~0.45 M in acetonitrile
技术
DNA synthesis: suitable
杂质
≤0.003% water
沸点
84 °C (lit.)
mp
156-158 °C (lit.)
密度
0.798 g/mL at 20 °C
SMILES字符串
c1nnn[nH]1
InChI
1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5)
InChI key
KJUGUADJHNHALS-UHFFFAOYSA-N
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一般描述
本品为约 0.45M 四唑乙腈溶液。四唑环在各种合成和工业生产过程中起重要的作用。
应用
四唑溶液可用于 DNA 合成。它可用作在原位 合成脱氧核苷亚磷酰胺的催化剂。可用于制备以下阴离子核苷酸脂质：
- 胸苷 3′-（1,2-二苯甲酰- 锡 -甘油-3-磷酸），diC 12 -3′-dT
- 胸苷 3′-（1,2-二肉豆蔻酰- 锡 -甘油-3-磷酸）diC 14 -3′-dT
- 胸苷-3′-（1,2-二棕榈酰- 锡 -甘油-3-磷酸）diC 16 -3′-dT
其他说明
寡核苷酸亚磷酸三酯法合成（二烷基氨基）膦偶联用催化剂
免责声明
室温下为饱和溶液；低于室温储存会产生沉淀。
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
41.0 °F - closed cup
闪点(°C)
5 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Azidoazomethine-tetrazole isomerism in solution: A thermochemical study.
Cubero E, et al.
The Journal of Organic Chemistry, 63(7), 2354-2356 (1998)
A D Barone et al.
Nucleic acids research, 12(10), 4051-4061 (1984-05-25)
Deoxynucleoside phosphoramidites can be prepared in good yield from deoxynucleosides, bis- dialkylaminophosphines , and the corresponding dialkylamine hydrotetrazolide or tetrazole as catalysts. These phosphoramidites generated in situ lead to the direct synthesis of deoxyoligonucleotides on polymer supports.
Salim Khiati et al.
Bioconjugate chemistry, 20(9), 1765-1772 (2009-08-29)
A family of new anionic nucleotide based lipids featuring thymidine-3'-monophosphate as nucleotide and 1,2-diacyl-sn-glycerol as lipid moiety for in vitro delivery of nucleic acids is described. The nucleotide lipids were prepared in three steps starting from 1,2-diacyl-sn-glycerols and 2'-deoxythymidine-3'-phosphoramidite. Gel
J Nielsen et al.
Nucleic acids research, 14(18), 7391-7403 (1986-09-25)
Deoxyribonucleoside phosphoramidites are prepared in situ from 5'-O,N-protected deoxyribonucleosides and 2-cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite with tetrazole as catalyst, and the solutions applied directly on an automatic solid-phase DNA synthesizer. Using LCAA-CPG support and a cycle time of 12.5 min, oligonucleotides of 16-25
Velladurai Rama et al.
The Journal of organic chemistry, 76(21), 9090-9095 (2011-09-14)
A simple and efficient route for the synthesis of 5-substituted 1H-tetrazoles catalyzed by CoY zeolite is reported. The salient features of this atom-economical, cost-effective, and high-yield cobalt-catalyzed protocol are aerobic conditions, lower reaction time, and milder reaction conditions without additives.
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