88185
四唑 溶液
~0.45 M in acetonitrile, solution, suitable for DNA synthesis, filtered through a 1 μm filter
别名:
1H-Tetrazole
产品名称
四唑 溶液, suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile
表单
liquid
质量水平
质量
filtered through a 1 μm filter
浓度
~0.45 M in acetonitrile
技术
DNA synthesis: suitable
杂质
≤0.003% water
沸点
84 °C (lit.)
mp
156-158 °C (lit.)
密度
0.798 g/mL at 20 °C
SMILES字符串
c1nnn[nH]1
InChI
1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5)
InChI key
KJUGUADJHNHALS-UHFFFAOYSA-N
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一般描述
本品为约 0.45M 四唑乙腈溶液。四唑环在各种合成和工业生产过程中起重要的作用。
应用
四唑溶液可用于 DNA 合成。它可用作在原位 合成脱氧核苷亚磷酰胺的催化剂。可用于制备以下阴离子核苷酸脂质：
- 胸苷 3′-（1,2-二苯甲酰- 锡 -甘油-3-磷酸），diC 12 -3′-dT
- 胸苷 3′-（1,2-二肉豆蔻酰- 锡 -甘油-3-磷酸）diC 14 -3′-dT
- 胸苷-3′-（1,2-二棕榈酰- 锡 -甘油-3-磷酸）diC 16 -3′-dT
其他说明
寡核苷酸亚磷酸三酯法合成（二烷基氨基）膦偶联用催化剂
免责声明
室温下为饱和溶液；低于室温储存会产生沉淀。
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
41.0 °F - closed cup
闪点(°C)
5 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Azidoazomethine-tetrazole isomerism in solution: A thermochemical study.
Cubero E, et al.
The Journal of Organic Chemistry, 63(7), 2354-2356 (1998)
A D Barone et al.
Nucleic acids research, 12(10), 4051-4061 (1984-05-25)
Deoxynucleoside phosphoramidites can be prepared in good yield from deoxynucleosides, bis- dialkylaminophosphines , and the corresponding dialkylamine hydrotetrazolide or tetrazole as catalysts. These phosphoramidites generated in situ lead to the direct synthesis of deoxyoligonucleotides on polymer supports.
Salim Khiati et al.
Bioconjugate chemistry, 20(9), 1765-1772 (2009-08-29)
A family of new anionic nucleotide based lipids featuring thymidine-3'-monophosphate as nucleotide and 1,2-diacyl-sn-glycerol as lipid moiety for in vitro delivery of nucleic acids is described. The nucleotide lipids were prepared in three steps starting from 1,2-diacyl-sn-glycerols and 2'-deoxythymidine-3'-phosphoramidite. Gel
Yuko Yoshikawa et al.
Inorganic chemistry, 50(22), 11729-11735 (2011-10-19)
We investigated the effects of antitumor-active tetrazolato-bridged dinuclear platinum(II) complexes [{cis-Pt(NH(3))(2)}(2)(μ-OH)(μ-tetrazolato-N(1),N(2))](2+) (1) and [{cis-Pt(NH(3))(2)}(2)(μ-OH)(μ-tetrazolato-N(2),N(3))](2+) (2) on the higher-order structure of a large DNA molecule (T4 phage DNA, 166 kbp) in aqueous solution through single-molecule observation by fluorescence microscopy. Complexes 1
Zhipeng Yu et al.
Journal of the American Chemical Society, 133(31), 11912-11915 (2011-07-09)
Photoactivatable fluorescent probes are invaluable tools for the study of biological processes with high resolution in space and time. Numerous strategies have been developed in generating photoactivatable fluorescent probes, most of which rely on the photo-"uncaging" and photoisomerization reactions. To
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