89126
西替利嗪 二盐酸盐
≥98.0% (HPLC)
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经验公式（希尔记法）:
C21H25ClN2O3 · 2HCl
化学文摘社编号:
分子量:
461.81
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
西替利嗪 二盐酸盐, ≥98.0% (HPLC)
InChI
1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
SMILES string
Cl[H].Cl[H].OC(=O)COCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3
InChI key
PGLIUCLTXOYQMV-UHFFFAOYSA-N
assay
≥98.0% (HPLC)
form
powder
Quality Level
Gene Information
human ... HRH1(3269)
Application
西替利嗪（CTZ）可用于皮肤肥大细胞增多症（色素性荨麻疹）的研究。西替利嗪是一种抗组胺药，可在过敏研究中用作组胺1受体（H1R）的拮抗剂。
M Gschwandtner et al.
Allergy, 68(1), 37-47 (2012-11-20)
Defects in keratinocyte differentiation and skin barrier are important features of inflammatory skin diseases like atopic dermatitis. Mast cells and their main mediator histamine are abundant in inflamed skin and thus may contribute to disease pathogenesis. Human primary keratinocytes were
K Rossbach et al.
Neuroscience, 190, 89-102 (2011-06-22)
Histamine has long been recognised as a classical inducer of pruritus. However, the specific mechanism of histamine-induced itch has still not been fully understood. The H1 and H4 receptor appear to be key components in the induction of itch. The
Ko-Haung Lue et al.
International journal of pediatric otorhinolaryngology, 76(7), 994-1001 (2012-04-20)
Supplementary consumption of probiotics may temporarily alter the intestinal microflora of infants and children, thereby preventing and treating allergic disorders. To compare the clinical efficacy of levocetirizine with that of levocetirizine plus Lactobacillus johnsonii EM1 (Lj EM1) for treating perennial
Arnold Bahlmann et al.
Chemosphere, 89(11), 1278-1286 (2012-06-12)
Carbamazepine (CBZ), caffeine and cetirizine were monitored by enzyme-linked immunosorbent assays (ELISAs) in surface and wastewaters from Berlin, Germany. This fast and cost-efficient method enabled to assess the spatial and temporal variation of these anthropogenic markers in a high-throughput screening.
Benno Brinkhaus et al.
Annals of internal medicine, 158(4), 225-234 (2013-02-20)
Chinese translation Acupuncture is frequently used to treat seasonal allergic rhinitis (SAR) despite limited scientific evidence. To evaluate the effects of acupuncture in patients with SAR. Randomized, controlled multicenter trial. (ClinicalTrials.gov: NCT00610584) 46 specialized physicians in 6 hospital clinics and
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