90790
L-α-羟基戊二酸 二钠盐
≥98.0% (GC)
别名:
(S)-2-羟基戊二酸 二钠盐, (S)-2-羟基戊二酸二钠
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关于此项目
线性分子式:
C5H6O5Na2
化学文摘社编号:
分子量:
192.08
UNSPSC Code:
12352106
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5318042
Quality Level
assay
≥98.0% (GC)
form
powder or crystals
optical activity
[α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
impurities
≤6.0% water
relevant disease(s)
cancer
storage temp.
2-8°C
SMILES string
[O-]C(CC[C@@H](C([O-])=O)O)=O.[Na+].[Na+]
InChI
1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
InChI key
DZHFTEDSQFPDPP-QTNFYWBSSA-L
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General description
产气消化球菌（Peptococcus aerogenes）的无细胞提取物以NAD依赖性方式将谷氨酸代谢为α-羟基戊二酸。它是细菌的乙醛酸代谢过程中形成的中间体。
Application
L-α-羟基戊二酸二钠盐适用于收集缓冲液，用于提高缺氧诱导因子-1 α（HIF-1 α）的回收率，HIF-1 α是人肿瘤的缺氧标志物。它也适用于放射性标记的5mC-5hmC转化试验，以研究2-HG对甲基羟化酶TET家族的影响。
Biochem/physiol Actions
罕见的L-2-HG脱氢酶缺陷可引起L-α-羟基戊二酸积累，导致代谢紊乱L-2-羟基戊二酸尿症（L-2HGA）。L-2HGA与神经元缺陷、脑白质营养不良以及脑肿瘤风险增加有关。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hugh Colvin et al.
Scientific reports, 6, 36289-36289 (2016-11-09)
Deranged metabolism is a hallmark of cancer, playing a significant role in driving the disease process. One such example is the induction of carcinogenesis by the oncometabolite D-2 hydroxyglutarate (D-2HG), which is produced by the mutated enzyme isocitrate dehydrogenase (IDH)
Rapid separation of some common intermediates of microbial metabolism by thin-layer chromatography.
A S Bleiweis et al.
Analytical biochemistry, 20(2), 335-338 (1967-08-01)
A S Bleiweis et al.
Journal of bacteriology, 94(5), 1560-1564 (1967-11-01)
Aspergillus glaucus, cultured on sodium propionate-mineral salts medium, incorporates (14)C-glyoxylate into labeled alpha-hydroxyglutaric acid within 30 sec. Mycelial extracts retain this biosynthetic capacity, which is destroyed by heating. Propionyl-2-(14)C-coenzyme A also in incorporated into labeled alpha-hydroxyglutaric acid by these mycelial
The production of alpha-hydroxyglutaric acid from glutamic acid by cell-free preparations of Peptococcus aerogenes.
W M Johnson et al.
Canadian journal of biochemistry, 47(12), 1103-1107 (1969-12-01)
Xudong Fu et al.
Cell metabolism, 22(3), 508-515 (2015-07-21)
We discovered recently that the central metabolite α-ketoglutarate (α-KG) extends the lifespan of C. elegans through inhibition of ATP synthase and TOR signaling. Here we find, unexpectedly, that (R)-2-hydroxyglutarate ((R)-2HG), an oncometabolite that interferes with various α-KG-mediated processes, similarly extends
实验方案
We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 90790-10MG | 04061833381649 |
| 90790-50MG | 04061833381656 |
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