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Merck
CN

92131

Sigma-Aldrich

甲氧苄啶

≥99.0% (HPLC)

别名:

2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶, NSC 106568

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关于此项目

经验公式（希尔记法）:
C14H18N4O3
化学文摘社编号:
738-70-5
分子量:
290.32
Beilstein:
625127
EC 号:
212-006-2
MDL编号:
MFCD00036761
UNSPSC代码:
51285203
PubChem化学物质编号:
57653467
NACRES:
NA.85

主要文件

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生物来源

synthetic

质量水平

200

方案

≥99.0% (HPLC)

表单

powder

颜色

white to light yellow

mp

≥199.0 °C

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用机制

DNA synthesis | interferes
enzyme | inhibits

储存温度

2-8°C

SMILES字符串

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChI key

IEDVJHCEMCRBQM-UHFFFAOYSA-N

基因信息

human ... DHFRP1(573971), KCNH1(3756)
rat ... Dhfr(24312)

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相关类别

一般描述

化学结构：嘧啶

应用

主要作为抗细菌剂。 二氢叶酸还原酶抑制活性和原核酶选择性。
甲氧苄啶主要用作抗菌剂。用于结核分枝杆菌的敏感性研究和流感嗜血杆菌的耐药性研究。

生化/生理作用

甲氧苄啶是一种二氢叶酸还原酶抑制剂，对原核生物酶具有选择性。
通过原核生物特异的二氢叶酸还原酶（DHFR）抑制四氢叶酸的合成。

包装

1g、5g、25g

其他说明

将容器密闭保存在干燥通风的地方。对光敏感。在惰性气体下储存。对水分敏感。产品对光和水分敏感。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险声明

H302,H361d

危险分类

Acute Tox. 4 Oral - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000464499
0000464499
0000442936
0000442936
0000403241

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is Trimethoprim stable in solution?

    Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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R de Groot et al.
Antimicrobial agents and chemotherapy, 32(4), 477-484 (1988-04-01)
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Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since the 1970s, shigellosis has also been reported as a sexually transmitted infection in men who
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The Journal of antimicrobial chemotherapy, 62(1), 35-40 (2008-04-15)
The lack of oral treatment alternatives for enterococcal urinary tract infections (UTIs) has led to a renewed interest in trimethoprim. Enterococci can incorporate exogenously produced folates and thereby reverse the effect of trimethoprim. Although a large proportion of enterococci appear
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Antibiotic therapy during pregnancy may be beneficial and impacts positively on the reduction of adverse pregnancy outcomes. No studies have been done so far on the effects of daily Co-trimoxazole (CTX) prophylaxis on birth outcomes. A phase 3b randomized trial
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