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Merck
CN

93482

苯甲磺酰氟 溶液

~0.1 M in ethanol (T)

别名:

PMSF, 苄磺酰氟

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化学文摘社编号:
329-98-6
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
57653563
MDL number:
MFCD00007424
Beilstein/REAXYS Number:
2088311

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产品名称

苯甲磺酰氟 溶液, ~0.1 M in ethanol (T)

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

SMILES string

FS(=O)(=O)Cc1ccccc1

InChI key

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

biological source

microbial
synthetic

form

liquid

concentration

~0.1 M in ethanol (T)

density

0.797 g/mL at 20 °C

storage temp.

2-8°C

Quality Level

200

Application

苯甲基磺酰氟溶液被用作乳腺癌细胞系、纤维肉瘤细胞系和D5后脑和脊髓神经祖细胞的细胞裂解物缓冲液的组分。

Biochem/physiol Actions

施用PMSF可产生与其抗胆碱酯酶作用无关的镇痛作用，并延长中枢给药的β-内啡肽的镇痛作用。
苯甲基磺酰氟（PMSF）是丝氨酸蛋白酶抑制剂。它与蛋白酶的活性位点残基共价结合，抑制蛋白水解活性。PMSF可用在蛋白纯化过程中的细胞裂解物缓冲液中，防止靶蛋白降解。PMSF可有效抑制纳洛酮促发的戒断跳跃。

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

53.6 °F - closed cup

flash_point_c

12 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

法规信息

危险化学品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN3815
BCCM0399
BCCL2616
BCCL1411
BCCK3515

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What can Product 93482, Phenylmethanesulfonyl fluoride solution, be used for?

    PMSF is a serine protease inhibitor, inhibiting the activity of enzymes such as thrombin, trypsin, papain, chymotrypsin and proteinase K. It also inhibits mammalian acetylcholinesterases.

  6. How can I further dilute Product 93482, Phenylmethanesulfonyl fluoride solution?

    We would recommend that you use an anhydrous ethanol to further dilute this solution, since PMSF is very unstable in water.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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