Quality Level
biological source
microbial, synthetic
form
liquid
concentration
~0.1 M in ethanol (T)
density
0.797 g/mL at 20 °C
storage temp.
2-8°C
SMILES string
FS(=O)(=O)Cc1ccccc1
InChI
1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChI key
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Application
苯甲基磺酰氟溶液被用作乳腺癌细胞系、纤维肉瘤细胞系和D5后脑和脊髓神经祖细胞的细胞裂解物缓冲液的组分。
Biochem/physiol Actions
苯甲基磺酰氟（PMSF）是丝氨酸蛋白酶抑制剂。它与蛋白酶的活性位点残基共价结合，抑制蛋白水解活性。PMSF可用在蛋白纯化过程中的细胞裂解物缓冲液中，防止靶蛋白降解。PMSF可有效抑制纳洛酮促发的戒断跳跃。
施用PMSF可产生与其抗胆碱酯酶作用无关的镇痛作用，并延长中枢给药的β-内啡肽的镇痛作用。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
53.6 °F - closed cup
flash_point_c
12 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Nervous system regionalization entails axial allocation before neural differentiation
Metzis V, et al.
Cell, 175(4), 1105-1118 (2018)
SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERalpha breast cancer
Magnani L, et al.
bioRxiv, 380634-380634 (2018)
C Pinsky et al.
Life sciences, 31(12-13), 1193-1196 (1982-09-20)
Intraperitoneal (IP) injection of the serine proteinase inhibitor phenylmethylsulfonyl fluoride (PMSF) produced dose-dependent analgesia in Sprague-Dawley rats. AD50 was 2.9 +/- 1.4 (S.E.) mg kg-1, the analgesia was antagonized by naloxone but unaffected by atropine. PMSF significantly enhanced the analgesic
Phenylmethanesulfonyl fluoride, a serine protease inhibitor, suppresses naloxone-precipitated withdrawal jumping in morphine-dependent mice
Nemoto W, et al.
Neuropeptides, 47(3), 187-191 (2013)
Arwin J Brouwer et al.
Bioorganic & medicinal chemistry, 19(7), 2397-2406 (2011-03-23)
We have designed and synthesized novel irreversible serine protease inhibitors containing aliphatic sulfonyl fluorides as an electrophilic trap. These substituted taurine sulfonyl fluorides derived from taurine or protected amino acids were conveniently synthesized from β-aminoethanesulfonyl chlorides using KF/18-crown-6 or from
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 93482-50ML-F | 04061833282830 |
| 93482-250ML-F | 04061833282823 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持