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93750

(+)-氯化筒箭毒碱五水合物

Name: (+)-氯化筒箭毒碱 五水合物
Brand: SIGMA

From plant, ≥97.0% (TLC), nicotinic acetylcholine receptor antagonist, powder

别名:

(+)-Tubocurarine chloride hydrochloride pentahydrate, D-Tubocurarine dichloride pentahydrate, Tubarine pentahydrate

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关于此项目

经验公式（希尔记法）:

C₃₇H₄₂Cl₂N₂O₆ · 5H₂O

化学文摘社编号:

6989-98-6

分子量:

771.72

NACRES:

NA.77

PubChem Substance ID:

57653575

UNSPSC Code:

12352202

MDL number:

MFCD00150157

Beilstein/REAXYS Number:

3896374

Assay:

≥97.0% (TLC)

Form:

powder

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产品名称

(+)-氯化筒箭毒碱五水合物, ≥97.0% (TLC)

biological source

plant

Quality Level

200

assay

≥97.0% (TLC)

form

powder

optical activity

[α]20/D +195±5°, c = 0.5% in H₂O

impurities

~12% water

mp

275-280 °C (dec.) (lit.)

storage temp.

2-8°C

SMILES string

[Cl-].Cl[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4

InChI

1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1

InChI key

WMIZITXEJNQAQK-GGDSLZADSA-N

Gene Information

human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

Application

(+)-Tubocurarine chloride pentahydrate has been used:

as an acetylcholine receptor antagonist in synapse blocking experiment to study its effect on neuromuscular junction formation (NMJ) formation in a co-culture system of human skeletal muscles and human stem cell-derived motoneurons
to induce paralysis in zebrafish larvae to study whole-brain imaging of seizures by two-photon light-sheet microscopy
to block NMJ to study its role in myotube contraction

Biochem/physiol Actions

(+)-Tubocurarine chloride pentahydrate serves as a neuromuscular blocker.

Classical competitive antagonist of the nicotinic acetylcholine receptor. Structure-activity relationships and conformational studies for tubocurarine binding at the nicotinic AChR.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Fast whole-brain imaging of seizures in zebrafish larvae by two-photon light-sheet microscopy

de Vito G, et al.

Biomedical Optics Express, 1516-1536 null

Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation.

Richard Mills et al.

Molecular metabolism, 7, 12-22 (2017-11-22)

We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. A microfluidic device was used to model endocrine signaling and NMJ formation between primary mouse myoblast-derived myotubes and embryonic stem cell-derived motor

Acetylcholine receptor inhibition by d-tubocurarine involves both a competitive and a noncompetitive binding site as determined by stopped-flow measurements of receptor-controlled ion flux in membrane vesicles.

J W Karpen et al.

Biochemistry, 25(7), 1786-1792 (1986-04-08)

The issue of whether d-tubocurarine, the classical acetylcholine receptor inhibitor, inhibits the receptor by a competitive or noncompetitive mechanism has long been controversial. d-Tubocurarine, in this study, has been found to be both a competitive (KC = 120 nM) and

Power-effective scanning with AODs for 3D optogenic applications.

Pietro Ricci et al.

Journal of biophotonics, 15(4), e202100256-e202100256 (2022-01-10)

Two-photon (2P) excitation is a cornerstone approach widely employed in neuroscience microscopy for deep optical access and sub-micrometric-resolution light targeting into the brain. However, besides structural and functional imaging, 2P optogenetic stimulations are less routinary, especially in 3D. This is

Reconstruction scheme for excitatory and inhibitory dynamics with quenched disorder: application to zebrafish imaging.

Lorenzo Chicchi et al.

Journal of computational neuroscience, 49(2), 159-174 (2021-04-08)

An inverse procedure is developed and tested to recover functional and structural information from global signals of brains activity. The method assumes a leaky-integrate and fire model with excitatory and inhibitory neurons, coupled via a directed network. Neurons are endowed

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货号	GTIN
93750-1G	04061833283141
93750-250MG	04061833283158

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