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Merck
CN

94072

Sigma-Aldrich

鬼笔环肽–Atto 565

suitable for fluorescence, ≥80.0% (HPLC)

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About This Item

UNSPSC代码:
12352108
NACRES:
NA.32

质量水平

检测方案

≥80.0% (HPLC)

形式

solid

分子量

Mw 1394 g/mol

制造商/商品名称

ATTO-TEC GmbH

λ

in methanol

紫外吸收

λ: 562.0-568.0 nm Amax

适用性

suitable for fluorescence

储存温度

−20°C

相关类别

一般描述

Atto 565是一种新型荧光标记,属于若丹明染料类别。它显示出强吸收性、高荧光量子产率、高热稳定性和光稳定性,并且几乎没有三重态形成。Atto 565由两种异构体的混合物组成,它们具有几乎相同的光学吸收和发射波长。鬼笔环肽是一种从有毒蘑菇伞形毒蕈中分离出的真菌毒素。其毒性归因于其在肝脏和肌肉细胞中,与F肌动蛋白结合的能力。由于结合了鬼笔环肽,肌动蛋白丝变得非常稳定。研究人员已经发现鬼笔环肽仅会与肌动蛋白的聚合形式和寡聚形式结合,而不与单体肌动蛋白结合。已确定肌动蛋白-鬼笔环肽复合物的解离常数约为3 x 10-8。鬼笔环肽在反应速度上不同于鹅膏蕈碱。在高剂量水平下,小鼠或大鼠会在1或2小时内死亡。鬼笔环肽的荧光缀合物可用于标记肌动蛋白丝,从而用于组织学应用中。鬼笔环肽的某些结构特征是与肌动蛋白结合所必需的。但是,氨基酸7(g-d-二羟亮氨酸)的侧链可进行化学修饰,而对肌动蛋白的亲和力不会发生明显的损失。

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WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

高风险级别生物产品--病毒,疫苗等

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商品

Atto dyes are a series of fluorescent dyes that meet the critical needs of modern fluorescent technologies.

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