94577
DL-α-羟基戊二酸 二钠盐
≥95.0% (GC)
别名:
(RS)-2-羟基戊二酸 二钠盐, 2-羟基戊二酸二钠
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关于此项目
线性分子式:
C5H6O5Na2
化学文摘社编号:
分子量:
192.08
NACRES:
NA.28
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
产品名称
DL-α-羟基戊二酸 二钠盐, ≥95.0% (GC)
InChI key
DZHFTEDSQFPDPP-UHFFFAOYSA-L
SMILES string
[Na+].[Na+].OC(CCC([O-])=O)C([O-])=O
InChI
1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2
assay
≥95.0% (GC)
form
powder or crystals
impurities
≤6.0% water
storage temp.
2-8°C
2-8°C
Quality Level
Biochem/physiol Actions
α-羟基戊二酸的 D-（或 R-）对映体是一种具有诊断价值的癌症相关生物标志物，而 α-羟基戊二酸的 L-（或 S-）对映体是某些神经代谢和遗传性疾病的一种生物标志物。它在真核生物中的生理功能尚不清楚。它对大脑有毒，并且能增加患脑瘤的几率。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Cancer-associated IDH mutations: biomarker and therapeutic opportunities
K E Yen
Oncogene (2010)
Fang Wang et al.
Science (New York, N.Y.), 340(6132), 622-626 (2013-04-06)
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter residues in the enzyme active sites and confer a gain-of-function in cancer cells, resulting in the
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang
Nature (2009)
Cancer: A metabolic metamorphosis.
Abigail S Krall et al.
Nature, 496(7443), 38-40 (2013-04-05)
Jelena Lazovic et al.
Neuro-oncology, 14(12), 1465-1472 (2012-10-24)
The arginine 132 (R132) mutation of isocitrate dehydrogenase -1 (IDH1(R132)) results in production of 2-hydroxyglutarate (2-HG) and is associated with a better prognosis compared with wild-type (WT) in glioma patients. The majority of lower-grade gliomas express IDH1(R132), whereas this mutation
实验方案
We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.
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