D6821
盐酸多奈哌齐
≥98% (HPLC), powder, acetylcholinesterase inhibitor
别名:
1 H -茚-1-酮，2,3-二氢-5,6-二甲氧基-2-\ [\ [1-（苯甲基）-4-哌啶基] 甲基]-, 盐酸盐, E2020
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经验公式（希尔记法）:
C24H29NO3 · HCl
化学文摘社编号:
分子量:
415.95
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
盐酸多奈哌齐, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to off-white
溶解性
DMSO: ≥20 mg/mL
H2O: ≥20 mg/mL
储存温度
room temp
SMILES字符串
O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl
InChI
1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2
InChI key
HLJIZAKUNCTCQX-UHFFFAOYSA-N
基因信息
human ... ACHE(43)
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警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral - Eye Irrit. 2
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Gilbert Audira et al.
Biomolecules, 10(9) (2020-09-24)
Donepezil (DPZ) is an acetylcholinesterase inhibitor used for the clinical treatment of mild cognitive impairment. However, DPZ has been reported to have adverse effects, including causing abnormal cardiac rhythm, insomnia, vomiting, and muscle cramps. However, the existence of these effects
Samantha L McLean et al.
Behavioural brain research, 302, 73-80 (2015-09-04)
Cholinergic dysfunction has been shown to be central to the pathophysiology of Alzheimer's disease and has also been postulated to contribute to cognitive dysfunction observed in various psychiatric disorders, including schizophrenia. Deficits are found across a number of cognitive domains
Ayijiang Habaike et al.
Cytotechnology, 72(4), 539-549 (2020-05-21)
Aggregation of Aβ is a pathological hallmark of Alzheimer's disease (AD). The purpose of this study was to identify the protective roles of different polysaccharide components in Fomes officinalis Ames polysaccharides (FOAPs) against Aβ25-35-induced neurotoxicity in PC12 cells. Different doses
Haneul Kim et al.
Journal of ethnopharmacology, 211, 38-46 (2017-09-18)
The seeds of Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F Chow (Rhamnaceae) and the roots of Codonopsis lanceolata (Siedbold & Zucc.) Benth. & Hook. f ex Trautv. (Campanulaceae), contained in the DHP1402, have long been used for treating dementia
Donepezil for dementia due to Alzheimer's disease
Birks Jacqueline S and Harvey Richard J
Cochrane database of systematic reviews (Online), 6 (2018)
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