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D6821

盐酸多奈哌齐

Name: 盐酸多奈哌齐
Brand: SIGMA

≥98% (HPLC), powder, acetylcholinesterase inhibitor

别名:

1 H -茚-1-酮，2,3-二氢-5,6-二甲氧基-2-\ [\ [1-（苯甲基）-4-哌啶基] 甲基]-, 盐酸盐, E2020

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关于此项目

经验公式（希尔记法）:

C₂₄H₂₉NO₃ · HCl

化学文摘社编号:

120011-70-3

分子量:

415.95

UNSPSC Code:

12352200

PubChem Substance ID:

329798838

NACRES:

NA.77

MDL number:

MFCD00881312

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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产品名称

盐酸多奈哌齐, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥20 mg/mL, H₂O: ≥20 mg/mL

storage temp.

room temp

SMILES string

O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl

InChI

1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2

InChI key

HLJIZAKUNCTCQX-UHFFFAOYSA-N

Gene Information

human ... ACHE(43)

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Application

用盐酸多奈哌齐进行量效实验，研究其改善尼古丁戒断所致小鼠环境条件反应缺陷的作用。还将其腹腔注射到大鼠体内，研究其改善社会行为缺陷、重复行为和多动的能力。

Biochem/physiol Actions

盐酸多奈哌齐是一种含有有机化合物和非竞争性抑制剂的哌啶类药物。对治疗阿尔茨海默病（其中痴呆为突出症状）有效。已证实多奈哌齐可诱导认知能力和全身功能。其半衰期为 70 小时。

一水合盐酸多奈哌齐是一种可逆性乙酰胆碱酯酶抑制剂

盐酸多奈哌齐一水合物是一种中枢作用的可逆性乙酰胆碱酯酶抑制剂。

Features and Benefits

该化合物收录于受体分类和信号转导手册的乙酰胆碱合成和代谢页面。想要浏览手册的其他页面，请单击此处。

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000489307

0000481242

0000469194

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全球贸易项目编号

货号	GTIN
D6821-50MG	04061833587928
D6821-10MG	04061833587911

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