Merck
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安全信息

E8375

Sigma-Aldrich

毒扁豆碱

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别名:
伊色林
经验公式（希尔记法）:
C15H21N3O2
CAS号:
57-47-6
分子量:
275.35
Beilstein:
91230
EC 号:
200-332-8
MDL编号:
MFCD00151090
PubChem化学物质编号:
24277867

检测方案

≥99% (HPLC)

mp

102-104 °C (lit.)

SMILES字符串

[H][C@]12N(C)CC[C@@]1(C)c3cc(OC(=O)NC)ccc3N2C

InChI

1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1

InChI key

PIJVFDBKTWXHHD-HIFRSBDPSA-N

基因信息

human ... ACHE(43) , APP(351) , BCHE(590)
mouse ... Ache(11423) , Bche(12038) , Chrm1(12669)
rat ... Ache(83817) , Bche(65036) , Chrm2(81645)

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生化/生理作用

乙酰胆碱酯酶抑制剂越过血脑屏障并与乙酰胆碱酯酶形成缓慢降解的氨基甲酰酶络合物。

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) and Acetylcholine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H330

危险分类

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

储存分类代码

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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Federica Belluti et al.
Journal of medicinal chemistry, 48(13), 4444-4456 (2005-06-25)
In continuing research that led us to identify a new class of carbamate derivatives acting as potent (Rampa et al. J. Med. Chem. 1998, 41, 3976) and long-lasting (Rampa et al. J. Med. Chem. 2001, 44, 3810) acetylcholinesterase (AChE) inhibitors
Ciaran G Carolan et al.
Journal of medicinal chemistry, 51(20), 6400-6409 (2008-09-27)
In this study, we report the SAR and characterization of two groups of isosorbide-based cholinesterase inhibitors. The first was based directly on the clinically used nitrate isosorbide mononitrate (ISMN) retention of the 5-nitrate group and introduction of a series of
Irina Esterlis et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(1), 78-82 (2012-11-20)
In vivo estimation of β(2)-nicotinic acetylcholine receptor availability with molecular neuroimaging is complicated by competition between the endogenous neurotransmitter acetylcholine and the radioligand (123)I-3-[2(S)-2-azetidinylmethoxy]pyridine ((123)I-5-IA). We examined whether binding of (123)I-5-IA is sensitive to increases in extracellular levels of acetylcholine
K L Cheng et al.
Hong Kong medical journal = Xianggang yi xue za zhi, 19(1), 38-41 (2013-02-05)
To study the epidemiology, causes, and clinical course of Chinese herbal medicine-induced anticholinergic poisoning in Hong Kong. Case series. Hong Kong. All case histories of Chinese herbal medicine-induced anticholinergic poisoning (with laboratory confirmation) recorded by the Hong Kong Poison Information
Emiliano Ricciardi et al.
Neuropharmacology, 64, 305-313 (2012-08-22)
Enhancing cholinergic function improves performance on various cognitive tasks and alters neural responses in task specific brain regions. We have hypothesized that the changes in neural activity observed during increased cholinergic function reflect an increase in neural efficiency that leads
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