方案
≥99% (HPLC)
mp
102-104 °C (lit.)
SMILES字符串
[H][C@]12N(C)CC[C@@]1(C)c3cc(OC(=O)NC)ccc3N2C
InChI
1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
InChI key
PIJVFDBKTWXHHD-HIFRSBDPSA-N
基因信息
human ... ACHE(43), APP(351), BCHE(590)
mouse ... Ache(11423), Bche(12038), Chrm1(12669)
rat ... Ache(83817), Bche(65036), Chrm2(81645)
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生化/生理作用
乙酰胆碱酯酶抑制剂越过血脑屏障并与乙酰胆碱酯酶形成缓慢降解的氨基甲酰酶络合物。
可越过血脑屏障的乙酰胆碱酯酶抑制剂。
特点和优势
This compound is featured on the Acetylcholine Receptors (Nicotinic) and Acetylcholine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
储存分类代码
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
S J Reed et al.
British journal of anaesthesia, 110(4), 646-653 (2012-12-06)
Positron emission tomography studies in human subjects show that propofol-induced unconsciousness in humans is associated with a reduction in thalamic blood flow, suggesting that anaesthesia is associated with impairment of thalamic function. A recent study showed that antagonism of propofol-induced
K L Cheng et al.
Hong Kong medical journal = Xianggang yi xue za zhi, 19(1), 38-41 (2013-02-05)
To study the epidemiology, causes, and clinical course of Chinese herbal medicine-induced anticholinergic poisoning in Hong Kong. Case series. Hong Kong. All case histories of Chinese herbal medicine-induced anticholinergic poisoning (with laboratory confirmation) recorded by the Hong Kong Poison Information
Emiliano Ricciardi et al.
Neuropharmacology, 64, 305-313 (2012-08-22)
Enhancing cholinergic function improves performance on various cognitive tasks and alters neural responses in task specific brain regions. We have hypothesized that the changes in neural activity observed during increased cholinergic function reflect an increase in neural efficiency that leads
Anna M Lilja et al.
PloS one, 8(1), e54887-e54887 (2013-02-06)
Neuronal dysfunction and demise together with a reduction in neurogenesis are cardinal features of Alzheimer's disease (AD) induced by a combination of oxidative stress, toxic amyloid-β peptide (Aβ) and a loss of trophic factor support. Amelioration of these was assessed
Ciaran G Carolan et al.
Journal of medicinal chemistry, 53(3), 1190-1199 (2010-01-14)
Isosorbide-2-benzyl carbamate-5-benzoate is a highly potent and selective BuChE inhibitor. Meanwhile, isosorbide-2-aspirinate-5-salicylate is a highly effective aspirin prodrug that relies on the salicylate portion to interact productively with human BuChE. By integrating the salicylate group into the carbamate design, we
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