E8375
毒扁豆碱
别名:
伊色林
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关于此项目
经验公式（希尔记法）:
C15H21N3O2
化学文摘社编号:
分子量:
275.35
EC Number:
200-332-8
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
91230
MDL number:
InChI key
PIJVFDBKTWXHHD-HIFRSBDPSA-N
InChI
1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
SMILES string
[H][C@]12N(C)CC[C@@]1(C)c3cc(OC(=O)NC)ccc3N2C
assay
≥99% (HPLC)
mp
102-104 °C (lit.)
Gene Information
human ... ACHE(43), APP(351), BCHE(590)
mouse ... Ache(11423), Bche(12038), Chrm1(12669)
rat ... Ache(83817), Bche(65036), Chrm2(81645)
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Biochem/physiol Actions
乙酰胆碱酯酶抑制剂越过血脑屏障并与乙酰胆碱酯酶形成缓慢降解的氨基甲酰酶络合物。
可越过血脑屏障的乙酰胆碱酯酶抑制剂。
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Nicotinic) and Acetylcholine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Irina Esterlis et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(1), 78-82 (2012-11-20)
In vivo estimation of β(2)-nicotinic acetylcholine receptor availability with molecular neuroimaging is complicated by competition between the endogenous neurotransmitter acetylcholine and the radioligand (123)I-3-[2(S)-2-azetidinylmethoxy]pyridine ((123)I-5-IA). We examined whether binding of (123)I-5-IA is sensitive to increases in extracellular levels of acetylcholine
Ciaran G Carolan et al.
Journal of medicinal chemistry, 51(20), 6400-6409 (2008-09-27)
In this study, we report the SAR and characterization of two groups of isosorbide-based cholinesterase inhibitors. The first was based directly on the clinically used nitrate isosorbide mononitrate (ISMN) retention of the 5-nitrate group and introduction of a series of
Federica Belluti et al.
Journal of medicinal chemistry, 48(13), 4444-4456 (2005-06-25)
In continuing research that led us to identify a new class of carbamate derivatives acting as potent (Rampa et al. J. Med. Chem. 1998, 41, 3976) and long-lasting (Rampa et al. J. Med. Chem. 2001, 44, 3810) acetylcholinesterase (AChE) inhibitors
Emiliano Ricciardi et al.
Neuropharmacology, 64, 305-313 (2012-08-22)
Enhancing cholinergic function improves performance on various cognitive tasks and alters neural responses in task specific brain regions. We have hypothesized that the changes in neural activity observed during increased cholinergic function reflect an increase in neural efficiency that leads
K L Cheng et al.
Hong Kong medical journal = Xianggang yi xue za zhi, 19(1), 38-41 (2013-02-05)
To study the epidemiology, causes, and clinical course of Chinese herbal medicine-induced anticholinergic poisoning in Hong Kong. Case series. Hong Kong. All case histories of Chinese herbal medicine-induced anticholinergic poisoning (with laboratory confirmation) recorded by the Hong Kong Poison Information
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