F9128
5′-(4-氟磺酰基苯甲酰基)腺苷 盐酸盐
≥95% (TLC), synthetic (organic), powder
别名:
FSBA, 三磷酸腺苷-5′-(4-氟磺酰基苯甲酸酯) 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H16FN5O7S · HCl
化学文摘社编号:
分子量:
489.86
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
8178939
Assay:
≥95% (TLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
methanol: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
产品名称
5′-(4-氟磺酰基苯甲酰基)腺苷 盐酸盐,
InChI
1S/C17H16FN5O7S.ClH/c18-31(27,28)9-3-1-8(2-4-9)17(26)29-5-10-12(24)13(25)16(30-10)23-7-22-11-14(19)20-6-21-15(11)23;/h1-4,6-7,10,12-13,16,24-25H,5H2,(H2,19,20,21);1H/t10-,12-,13-,16-;/m1./s1
SMILES string
Cl[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COC(=O)c4ccc(cc4)S(F)(=O)=O)[C@@H](O)[C@H]3O
InChI key
ZUHVYHQVJYIHPN-KHXPSBENSA-N
biological source
synthetic (organic)
assay
≥95% (TLC)
form
powder
solubility
methanol: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
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Application
5′-（4-氟磺酰基苯甲酰基）腺苷盐酸盐可用于与 Ime2（减数分裂 2 的诱导剂）孵育以确定 Ime2 对三磷酸腺苷（ATP）类似物 5′-氟磺酰基苯甲酰腺苷（FSBA）的敏感性。
5′-（4-氟磺酰基苯甲酰基）腺苷（FSBA）是 ATP 类似物，用于研究渥曼青霉素的作用机理。FSBA 已用于研究肠道细胞（例如 Caco-2）中的囊泡运输，并对各种 ATP 酶、激酶和其他蛋白质的核苷酸结合域（NBD）中的残基进行共价修饰。
Biochem/physiol Actions
由于 5′-（4-氟磺酰基苯甲酰基）腺苷与这些基序中发生的亲核氨基酸反应，因此其有助于识别激酶中的三磷酸腺苷（ATP）结合位点。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Steven J Ratcliffe et al.
Journal of biomolecular screening, 12(1), 126-132 (2006-12-15)
Most of the kinase inhibitors that are approved for therapeutic uses or that are undergoing clinical trials are directed toward the adenosine triphosphate (ATP) binding site of protein kinases. 5'-Fluorosulfonylbenzoyl 5'-adenosine (FSBA) is an activitybased probe (ABP) that covalently modifies
Sanjay S Khandekar et al.
Journal of biomolecular screening, 10(5), 447-455 (2005-08-12)
The currently approved kinase inhibitors for therapeutic uses and a number of kinase inhibitors that are undergoing clinical trials are directed toward the adenosine triphosphate (ATP) binding site of protein kinases. The 5'-fluorosulfonylbenzoyl 5'-adenosine (FSBA) is an ATP-affinity reagent that
Eric Faudry et al.
The Journal of biological chemistry, 279(19), 19607-19613 (2004-02-27)
Apyrases are nucleoside triphosphate-diphosphohydrolases (EC 3.6.1.5) present in a variety of organisms. The apyrase activity found in the saliva of hematophagous insects is correlated with the prevention of ADP-induced platelet aggregation of the host during blood sucking. Purification of apyrase
Kenichi A Tanaka et al.
Platelets, 15(5), 325-332 (2004-09-17)
The use of clopidogrel (Plavix), an inhibitor of adenosine diphosphate (ADP)-induced platelet aggregation, has been proven to reduce ischemic events in cardiovascular patients, but little information is available for optimal monitoring of platelet function in patients receiving the drug preoperatively.
Giovanni Renzone et al.
Proteins, 67(1), 189-197 (2007-01-24)
Sso7d from the extreme thermophilic crenarchaeon Sulfolobus solfataricus is a multifunctional protein in in vitro assays, whose in vivo role is still puzzling. Crystals of Sso7d in complex with DNA elucidated the protein surface involved in the binding to the
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