F9128
5′-(4-氟磺酰基苯甲酰基)腺苷 盐酸盐
≥95% (TLC), synthetic (organic), powder
别名:
FSBA, 三磷酸腺苷-5′-(4-氟磺酰基苯甲酸酯) 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H16FN5O7S · HCl
化学文摘社编号:
分子量:
489.86
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
8178939
产品名称
5′-(4-氟磺酰基苯甲酰基)腺苷 盐酸盐,
InChI
1S/C17H16FN5O7S.ClH/c18-31(27,28)9-3-1-8(2-4-9)17(26)29-5-10-12(24)13(25)16(30-10)23-7-22-11-14(19)20-6-21-15(11)23;/h1-4,6-7,10,12-13,16,24-25H,5H2,(H2,19,20,21);1H/t10-,12-,13-,16-;/m1./s1
SMILES string
Cl[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COC(=O)c4ccc(cc4)S(F)(=O)=O)[C@@H](O)[C@H]3O
InChI key
ZUHVYHQVJYIHPN-KHXPSBENSA-N
biological source
synthetic (organic)
assay
≥95% (TLC)
form
powder
solubility
methanol: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
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Application
5′-（4-氟磺酰基苯甲酰基）腺苷盐酸盐可用于与 Ime2（减数分裂 2 的诱导剂）孵育以确定 Ime2 对三磷酸腺苷（ATP）类似物 5′-氟磺酰基苯甲酰腺苷（FSBA）的敏感性。
5′-（4-氟磺酰基苯甲酰基）腺苷（FSBA）是 ATP 类似物，用于研究渥曼青霉素的作用机理。FSBA 已用于研究肠道细胞（例如 Caco-2）中的囊泡运输，并对各种 ATP 酶、激酶和其他蛋白质的核苷酸结合域（NBD）中的残基进行共价修饰。
Biochem/physiol Actions
由于 5′-（4-氟磺酰基苯甲酰基）腺苷与这些基序中发生的亲核氨基酸反应，因此其有助于识别激酶中的三磷酸腺苷（ATP）结合位点。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
P Borowski et al.
Biological chemistry, 380(4), 403-412 (1999-06-04)
A detergent extract isolated from the enriched fraction of integral membrane proteins of Jurkat cells showed an enhanced tyrosine phosphate level when phosphorylated in the presence of phorbol 12-myristate 13-acetate (TPA) and phorbol 12,13-dibutyrate (PDBu). The enhanced tyrosine phosphorylation was
Xavier Hanoulle et al.
Journal of proteome research, 5(12), 3438-3445 (2006-12-02)
Adenine nucleotides are small, abundant molecules that bind numerous proteins involved in pivotal cellular processes. These nucleotides are co-factors or substrates for enzymes, regulators of protein function, or structural binding motifs. The identification of nucleotide-binding sites on a proteome-wide scale
Dinesh Manvar et al.
Biochemistry, 52(2), 432-444 (2012-12-28)
We have used an ATP analogue 5'-[p-(fluorosulfonyl)benzoyl]adenosine (FSBA) to modify HCV replicase in order to identify the ATP binding site in the enzyme. FSBA inactivates HCV replicase activity in a concentration-dependent manner with a binding stoichiometry of 2 moles of
Sanjay S Khandekar et al.
Journal of biomolecular screening, 10(5), 447-455 (2005-08-12)
The currently approved kinase inhibitors for therapeutic uses and a number of kinase inhibitors that are undergoing clinical trials are directed toward the adenosine triphosphate (ATP) binding site of protein kinases. The 5'-fluorosulfonylbenzoyl 5'-adenosine (FSBA) is an ATP-affinity reagent that
Steven J Ratcliffe et al.
Journal of biomolecular screening, 12(1), 126-132 (2006-12-15)
Most of the kinase inhibitors that are approved for therapeutic uses or that are undergoing clinical trials are directed toward the adenosine triphosphate (ATP) binding site of protein kinases. 5'-Fluorosulfonylbenzoyl 5'-adenosine (FSBA) is an activitybased probe (ABP) that covalently modifies
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