I5159
咪喹莫特
≥98% (HPLC), solid, caspase 3 activator
别名:
1-（2-甲基丙基）-1 H -咪唑 [4,5- c ] 喹啉-4-胺
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关于此项目
经验公式（希尔记法）:
C14H16N4
化学文摘社编号:
分子量:
240.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
咪喹莫特, ≥98% (HPLC), solid
SMILES string
CC(C)Cn1cnc2c(N)nc3ccccc3c12
InChI key
DOUYETYNHWVLEO-UHFFFAOYSA-N
InChI
1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
assay
≥98% (HPLC)
form
solid
solubility
H2O: <2 mg/mL
DMSO: 4 mg/mL (warming to 60 °C for 15 minutes)
Quality Level
Gene Information
human ... TLR7(51284)
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Biochem/physiol Actions
咪喹莫特是半胱天冬酶 3 激活剂，可直接诱导半胱天冬酶 3 裂解为活性半胱天冬酶 3。咪喹莫特在体内 诱导基底细胞癌凋亡 。其抗肿瘤活性与诱导细胞凋亡有关。咪喹莫特具有抗血管生成、抗炎、抗病毒活性。咪喹莫特还可作为免疫应答调节剂，诱导多种细胞因子和趋化因子的分泌。
咪喹莫特是半胱天冬酶 3 激活剂，可直接诱导半胱天冬酶 3 裂解为活性半胱天冬酶 3。咪喹莫特在体内可诱导细胞凋亡 ，并作为一种免疫调节剂，具有抗病毒和抗炎特性。
Imiquimod helps to induce the innate cutaneous immunity and the cellular arm of the adaptive immune response.
Application
Imiquimod has been used as TLR7 agonist for TLR7 agonist enhancement studies. It has also been used as an NLR family, pyrin domain containing 3 (NLRP3) stimulant to treat NLRP3-FL-Btn and FLAG-ASC-FL.
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
Imiquimod is a toll-like receptor (TLR)-7/8 agonist.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Aimée H M M Arits et al.
The Lancet. Oncology, 14(7), 647-654 (2013-05-21)
Superficial basal-cell carcinoma is most commonly treated with topical non-surgical treatments, such as photodynamic therapy or topical creams. Photodynamic therapy is considered the preferable treatment, although this has not been previously tested in a randomised control trial. We assessed the
Topical imiquimod is and effective and safe drug for molluscum contagiosum in children
Badavanis G, et al.
Acta Dermatovenerologica Croatica, 25(2), 164-164 (2017)
Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7
Coleman L G, et al.
Journal of Neuroinflammation, 14(1), 22-22 (2017)
Poly (I: C) and hyaluronic acid directly interact with NLRP3, resulting in the assembly of NLRP3 and ASC in a cell-free system
Kaneko N, et al.
European journal of inflammation, 15(2), 85-97 (2017)
Anne Walter et al.
Nature communications, 4, 1560-1560 (2013-03-07)
Aldara is a cream used for topical treatment of non-melanoma skin cancer, and is thought to act through stimulation of anti-tumour immunity. The active ingredient, imiquimod, has been shown to stimulate toll-like receptor 7. Aldara also induces psoriasis-like lesions when
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