biological source
Escherichia coli (O111:B4)
Quality Level
form
aqueous solution
concentration
1 mg/mL
color
colorless to faint yellow
solubility
water: soluble
shipped in
wet ice
storage temp.
2-8°C
Application
大肠肝菌O111:B4来源脂多糖可用于：
- 刺激体内猪的肝脏组织和体外仔猪回肠组织的炎症反应
- 刺激体外自然杀手(NK)细胞和肝B细胞
- 在标准兔模型中诱发关节炎
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。
Biochem/physiol Actions
脂多糖(LPS)分布在细胞膜的外层，并且存在于无包膜菌株的细胞表面。LPS可维持外膜的完整性。此外，还可保护细胞免受胆盐应激和亲脂抗生素的影响。
Preparation Note
产物可溶于水（5mg/ml）或细胞培养基（1mg/ml），产生浑浊的、淡黄色溶液。在经过涡旋和加温至 70-80oC 后，在水溶的盐水中得到更浓缩、但仍然浑浊的溶液（20mg/ml）。脂多糖是在各种溶剂中形成胶束的分子。在水和磷酸盐缓冲盐水中观察到浑浊的溶液。有机溶剂不能提供更澄清的溶液。甲醇产生具有漂浮物的混浊悬浮液，而水产生均匀混浊的溶液。
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存储类别
12 - Non Combustible Liquids
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L5293-2ML | 04061833958032 |