P9391
普鲁卡因胺 盐酸盐
别名:
4-氨基-N-（2-二乙氨基乙基）苯甲酰胺 盐酸盐, 4-氨基苯甲酸-2-二乙氨基乙酰胺
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关于此项目
线性分子式:
H2NC6H4CONHCH2CH2N(C2H5)2·HCl
化学文摘社编号:
分子量:
271.79
EC Number:
210-381-7
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
3729517
MDL number:
InChI key
ABTXGJFUQRCPNH-UHFFFAOYSA-N
InChI
1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H
SMILES string
Cl.CCN(CC)CCNC(=O)c1ccc(N)cc1
form
powder
mp
167-169 °C (lit.)
solubility
H2O: soluble
ethanol: soluble
originator
Bristol-Myers Squibb
Gene Information
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Biochem/physiol Actions
Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Na+ channel blocker and Class IA anti-arrhythmic.
Features and Benefits
This compound is a featured product for ADME Tox and Gene Regulation research. Discover more featured ADME Tox and Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Y H Kim et al.
Circulation, 100(6), 666-674 (1999-08-10)
Ventricular fibrillation (VF) is maintained by 2 mechanisms: first by reentry formation and second by spontaneous wave break or wave splitting. We hypothesized that spontaneous wave break results from a critical shortening of the action potential duration (APD) during VF
Fei Li et al.
Biochemical pharmacology, 83(10), 1435-1444 (2012-03-06)
Procainamide, a type I antiarrhythmic agent, is used to treat a variety of atrial and ventricular dysrhythmias. It was reported that long-term therapy with procainamide may cause lupus erythematosus in 25-30% of patients. Interestingly, procainamide does not induce lupus erythematosus
Z Wojnarowska et al.
The Journal of chemical physics, 136(16), 164507-164507 (2012-05-09)
The pharmaceuticals, procaine hydrochloride and procainamide hydrochloride, are glass-forming as well as ionically conducting materials. We have made dielectric measurements at ambient and elevated pressures to characterize the dynamics of the ion conductivity relaxation in these pharmaceuticals, and calorimetric measurements
Ludovic Halby et al.
Chembiochem : a European journal of chemical biology, 13(1), 157-165 (2011-12-16)
DNA methyltransferases (DNMTs) are responsible for DNA methylation, an epigenetic modification involved in gene regulation. Families of conjugates of procainamide, an inhibitor of DNMT1, were conceived and produced by rapid synthetic pathways. Six compounds resulted in potent inhibitors of the
Malyaj Narwaley et al.
Chemical research in toxicology, 24(7), 1031-1039 (2011-06-16)
Aromatic amine drugs like aminoglutethimide (AG) and related congeners have been shown to produce phenyl radicals through metabolism by myeloperoxidase (MPO)/H(2)O(2), which has been proposed to play a role in drug-induced agranulocytosis. AG has also been shown to induce MPO
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