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P9391

普鲁卡因胺 盐酸盐

别名:

4-氨基-N-（2-二乙氨基乙基）苯甲酰胺 盐酸盐, 4-氨基苯甲酸-2-二乙氨基乙酰胺

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关于此项目

线性分子式:
H2NC6H4CONHCH2CH2N(C2H5)2·HCl
化学文摘社编号:
614-39-1
分子量:
271.79
EC Number:
210-381-7
UNSPSC Code:
12352200
PubChem Substance ID:
24277864
Beilstein/REAXYS Number:
3729517
MDL number:
MFCD00012998
Form:
powder
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form

powder

mp

167-169 °C (lit.)

solubility

H2O: soluble, ethanol: soluble

originator

Bristol-Myers Squibb

SMILES string

Cl.CCN(CC)CCNC(=O)c1ccc(N)cc1

InChI

1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H

InChI key

ABTXGJFUQRCPNH-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Biochem/physiol Actions

Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Na+ channel blocker and Class IA anti-arrhythmic.

Features and Benefits

This compound is a featured product for ADME Tox and Gene Regulation research. Discover more featured ADME Tox and Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBC2834V
WXBC2443V
MKBS4413V
SLBG4388V
129K1962V

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Y H Kim et al.
Circulation, 100(6), 666-674 (1999-08-10)
Ventricular fibrillation (VF) is maintained by 2 mechanisms: first by reentry formation and second by spontaneous wave break or wave splitting. We hypothesized that spontaneous wave break results from a critical shortening of the action potential duration (APD) during VF
Ian G Stiell et al.
Annals of emergency medicine, 57(1), 13-21 (2010-09-25)
Although recent-onset atrial fibrillation and flutter are common arrhythmias managed in the emergency department (ED), there is insufficient evidence to help physicians choose between 2 competing treatment strategies, rate control and rhythm control. We seek to evaluate variation in ED
Ludovic Halby et al.
Chembiochem : a European journal of chemical biology, 13(1), 157-165 (2011-12-16)
DNA methyltransferases (DNMTs) are responsible for DNA methylation, an epigenetic modification involved in gene regulation. Families of conjugates of procainamide, an inhibitor of DNMT1, were conceived and produced by rapid synthetic pathways. Six compounds resulted in potent inhibitors of the
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