P9391
普鲁卡因胺 盐酸盐
别名:
4-氨基-N-（2-二乙氨基乙基）苯甲酰胺 盐酸盐, 4-氨基苯甲酸-2-二乙氨基乙酰胺
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关于此项目
线性分子式:
H2NC6H4CONHCH2CH2N(C2H5)2·HCl
化学文摘社编号:
分子量:
271.79
EC Number:
210-381-7
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
3729517
MDL number:
InChI key
ABTXGJFUQRCPNH-UHFFFAOYSA-N
InChI
1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H
SMILES string
Cl.CCN(CC)CCNC(=O)c1ccc(N)cc1
form
powder
mp
167-169 °C (lit.)
solubility
H2O: soluble
ethanol: soluble
originator
Bristol-Myers Squibb
Gene Information
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Biochem/physiol Actions
Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Na+ channel blocker and Class IA anti-arrhythmic.
Features and Benefits
This compound is a featured product for ADME Tox and Gene Regulation research. Discover more featured ADME Tox and Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Y H Kim et al.
Circulation, 100(6), 666-674 (1999-08-10)
Ventricular fibrillation (VF) is maintained by 2 mechanisms: first by reentry formation and second by spontaneous wave break or wave splitting. We hypothesized that spontaneous wave break results from a critical shortening of the action potential duration (APD) during VF
Isabela Costa César et al.
Journal of mass spectrometry : JMS, 46(11), 1125-1130 (2011-11-30)
A liquid chromatography-electrospray ionization tandem mass spectrometry method was developed and validated for the simultaneous quantitation of nicorandil and its denitrated metabolite, N-(2-hydroxyethyl)-nicotinamide, in rat plasma. After a liquid-liquid extraction step, chromatographic separation was performed on a ShinPack C(18) column
Yi-Shiuan Lin et al.
Journal of biomedical science, 18, 3-3 (2011-01-12)
Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors azacytidine and 5-aza-2'-deoxycytidine for the treatment of myelodysplastic syndromes. But their use is
Assessment of His-Purkinje reserve: what is the mechanism of block?
James Kneller et al.
Heart rhythm, 9(3), 465-466 (2010-12-04)
M Odijk et al.
Biosensors & bioelectronics, 26(4), 1521-1527 (2010-08-24)
We have designed an integrated 3-electrode electrochemical cell on-chip with high analyte conversion rates for use in drug metabolism studies. The electrochemical cell contains platinum working and counter electrodes and an iridium oxide pseudo-reference electrode. The pseudo-reference electrode has a
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