T9777
Trypsin-chymotrypsin inhibitor
lyophilized powder
别名:
Bowman-Birk抑制剂
产品名称
胰蛋白酶-胰凝乳蛋白酶抑制剂 来源于大豆, lyophilized powder
biological source
Glycine max (soybean)
form
lyophilized powder
composition
Protein, 70-90% biuret
storage temp.
2-8°C
Quality Level
General description
Bowman-Birk抑制剂通过七个二硫键进行高度的交联，具有胰蛋白酶和胰凝乳蛋白酶抑制的空间上不同的结构域。
糜胰蛋白酶抑制剂属于植物蛋白酶抑制剂家族。它主要存在于豆类（Fabaceae）和谷物类（Poaceae）。糜胰蛋白酶抑制剂中保守的半胱氨酸残基之间有多个二硫键，可维持抑制环的结构稳定性和活性构象。糜胰蛋白酶具有抗癌性质。
Application
Bowman Birk蛋白酶抑制剂可通过减少不正确的DNA修复来防止辐射诱导的癌症生成，从而减少双着丝粒染色体的数量。
来源于大豆的糜胰蛋白酶抑制剂已被用于流式细胞术分离酶活性检测。它还被用于体外胃肠道 (GI) 消化研究，用于抑制I胰蛋白酶和糜蛋白酶。
Physical form
含有pH7.6磷酸缓冲盐的冻干粉
Analysis Note
1 mg蛋白可抑制≥0.5 mg具有每mg蛋白~10,000 BAEE活性的胰蛋白酶，或≥1.0 mg具有每mg蛋白~40 BTEE的糜蛋白酶。
Other Notes
在25℃、pH 7.6条件下，以BAEE为底物，一单位胰蛋白酶 = 每分钟产生0.001的ΔA253。反应体积 = 3.2 mL（1 cm光程）。
查看更多关于 胰蛋白酶抑制剂的信息。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
Evidence for ancient origins of Bowman-Birk inhibitors from Selaginella moellendorffii
James AM, et al.
Plant Cell, 29(3), 461-473 (2017)
The Bowman-Birk inhibitor from soybeans as an anticarcinogenic agent
Kennedy AR
American Journal of Clinical Nutrition, 68(6), 1406S-1412S (1998)
Yu Liu et al.
Viruses, 10(10) (2018-10-17)
The Bowman‒Birk inhibitor (BBI), a protease inhibitor derived from soybeans, has been extensively studied in anti-tumor and anti-inflammation research. We recently reported that BBI has an anti-HIV-1 property in primary human macrophages. Because HSV-2 infection plays a role in facilitating
Epitopes resistance to the simulated gastrointestinal digestion of beta-lactoglobulin submitted to two-step enzymatic modification
Villas-Boas M, et al.
Food Research International, 72, 191-197 (2015)
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS
Ruppenthal S, et al.
PLoS ONE, 13(1), e0191734-e0191734 (2018)
商品
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
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