T9777
Trypsin-chymotrypsin inhibitor
lyophilized powder
别名:
Bowman-Birk抑制剂
产品名称
胰蛋白酶-胰凝乳蛋白酶抑制剂 来源于大豆, lyophilized powder
生物来源
Glycine max (soybean)
质量水平
表单
lyophilized powder
组成
Protein, 70-90% biuret
储存温度
2-8°C
一般描述
Bowman-Birk抑制剂通过七个二硫键进行高度的交联，具有胰蛋白酶和胰凝乳蛋白酶抑制的空间上不同的结构域。
糜胰蛋白酶抑制剂属于植物蛋白酶抑制剂家族。它主要存在于豆类（Fabaceae）和谷物类（Poaceae）。糜胰蛋白酶抑制剂中保守的半胱氨酸残基之间有多个二硫键，可维持抑制环的结构稳定性和活性构象。糜胰蛋白酶具有抗癌性质。
应用
Bowman Birk蛋白酶抑制剂可通过减少不正确的DNA修复来防止辐射诱导的癌症生成，从而减少双着丝粒染色体的数量。
来源于大豆的糜胰蛋白酶抑制剂已被用于流式细胞术分离酶活性检测。它还被用于体外胃肠道 (GI) 消化研究，用于抑制I胰蛋白酶和糜蛋白酶。
外形
含有pH7.6磷酸缓冲盐的冻干粉
分析说明
1 mg蛋白可抑制≥0.5 mg具有每mg蛋白~10,000 BAEE活性的胰蛋白酶，或≥1.0 mg具有每mg蛋白~40 BTEE的糜蛋白酶。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Evidence for ancient origins of Bowman-Birk inhibitors from Selaginella moellendorffii
James AM, et al.
Plant Cell, 29(3), 461-473 (2017)
Yu Liu et al.
Viruses, 10(10) (2018-10-17)
The Bowman‒Birk inhibitor (BBI), a protease inhibitor derived from soybeans, has been extensively studied in anti-tumor and anti-inflammation research. We recently reported that BBI has an anti-HIV-1 property in primary human macrophages. Because HSV-2 infection plays a role in facilitating
Epitopes resistance to the simulated gastrointestinal digestion of beta-lactoglobulin submitted to two-step enzymatic modification
Villas-Boas M, et al.
Food Research International, 72, 191-197 (2015)
The Bowman-Birk inhibitor from soybeans as an anticarcinogenic agent
Kennedy AR
American Journal of Clinical Nutrition, 68(6), 1406S-1412S (1998)
Alfonso Clemente et al.
Molecular nutrition & food research, 54(3), 396-405 (2009-11-04)
Bowman-Birk inhibitors (BBI) from soybean and related proteins are naturally occurring protease inhibitors with potential health-promoting properties within the gastrointestinal tract. In this work, we have investigated the effects of soybean BBI proteins on HT29 colon adenocarcinoma cells, compared with
商品
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
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