氨苄西林 钠盐

Ampicillin sodium salt, belonging to the extended-spectrum β-lactam family, stands as a semisynthetic derivative of penicillin with versatile applications as a broad-spectrum antibiotic. It exerts inhibitory effects on bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby impeding peptidoglycan synthesis—an integral process in the formation of the bacterial cell wall. This antibiotic demonstrates activity against an extensive spectrum of bacteria, encompassing both Gram-positive and Gram-negative strains such as E. coli, β-lactam sensitive vancomycin-resistant Enterococcus (VRE), Staphylococcus aureus, and Streptococcus pneumoniae.

In research, ampicillin plays a pivotal role in microbiological, biochemical, and cell culture investigations. Its utilization in laboratories extends to studying antibiotic resistance and penetration limitations, exploring the synergistic interactions between multiple antibiotics, and serving as a crucial component for the selection and maintenance of recombinant plasmids in E. coli. Through these applications, ampicillin sodium salt contributes significantly to advancing the understanding of antibiotic efficacy, bacterial responses, and molecular processes, making it an indispensable tool in various facets of scientific research.

建议以 100mg/L 的抗菌用量用于细胞培养基中。
建议以 20-125μg/ml 的量用于氨苄西林抗性研究。
在 37°C 下可稳定 3 天。

作用方式：该ß-内酰胺抗生素通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。

耐药性机制：ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。

抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。

5g, 25g, 100g

This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. It is stable at 37°C for three days. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week.

Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.

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Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.