assay
≥97% (HPLC)
UniProt accession no.
storage temp.
−20°C
SMILES string
CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H](Cc7ccccc7)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O
Gene Information
human ... APP(351)
Biochem/physiol Actions
β-Amyloid peptide that forms fibrils in vitro that have the same structure and antigenicity as those found in Alzheimer′s patients.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J J Miguel-Hidalgo et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(3), 203-208 (1998-08-26)
We assessed the neuroprotective capabilities of S12024 (R,S 1-methyl 8-(2-morpholinylmethoxy)-1,2,3,4-tetrahydroquinoleine methane sulphonate) in a model of neuronal degeneration in the dentate gyrus of the rat hippocampus. Specific degeneration of a large part of neurons in the lateral blade of the
X A Alvarez et al.
Methods and findings in experimental and clinical pharmacology, 19(7), 471-479 (1997-12-31)
beta-amyloid (beta A) deposition is a key event in the etiopathogenesis of Alzheimer's disease (AD), contributing to neuronal degeneration and cognitive impairment in AD patients. Both neurotrophic and neurotoxic actions of beta A have been demonstrated in experimental conditions. In
T G Fletcher et al.
Protein science : a publication of the Protein Society, 6(3), 666-675 (1997-03-01)
The neurotoxicity of beta-amyloid protein (beta AP) fragments may be a result of their solution conformation, which is very sensitive to solution conditions. In this work we describe NMR and CD studies of the conformation of beta AP(12-28) in lipid