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A0257

阿托品 硫酸盐 一水合物

≥97% (TLC), crystalline, cholinergic receptor antagonist

别名:

(8-甲基-8-氮杂双环[3.2.1]辛-3-基) edno-(+/-)-α-(羟甲基)苯乙酸酯, 龙葵碱

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关于此项目

线性分子式:
(C17H23NO3)2 · H2SO4 · H2O
化学文摘社编号:
5908-99-6
分子量:
694.83
NACRES:
NA.32
PubChem Substance ID:
57653815
UNSPSC Code:
12352210
EC Number:
200-235-0
MDL number:
MFCD00074815
Beilstein/REAXYS Number:
6109275
Assay:
≥97% (TLC)
Form:
crystalline
Quality level:
200
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产品名称

阿托品 硫酸盐 一水合物, ≥97% (TLC), crystalline

Quality Level

200

assay

≥97% (TLC)

form

crystalline

color

white

mp

189-192 °C (A) (lit.)

solubility

ethanol: 200 mg/mL (stable for several days at 4 °C.), glycerol: 400 mg/mL (stable for several days at 4 °C.), H2O: 50 mg/mL (stable for several days at 4 °C.)

SMILES string

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

InChI key

JPKKQJKQTPNWTR-CHYDPLAESA-N

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

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相关类别

General description

Atropine is isolated from Atropa belladonna, Datura stramonium and Mandragora officinarum. It is a tertiary amine, which acts as a cholinergic receptor antagonist.

Application

Atropine sulfate salt hydrate has been used:
  • to assay specific binding of high-affinity 3-quinuclidinyl benzilate-3H ([3H]QNB) to the muscarinic acetylcholine receptor (mAChR)
  • to block the recovery phase of the aldicarb (Ald) response
  • as an analyte for liquid chromatography with tandem mass spectrometry (LC-MS/MS)
  • as a mAChR antagonist to block acetylcholine receptor

Biochem/physiol Actions

位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF7835V
WXBF5209V
WXBF1811V
BCCJ0141
BCCG8993

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Spinalization and locomotor training differentially affect muscarinic acetylcholine receptor type 2 abutting on alpha-motoneurons innervating the ankle extensor and flexor muscles
Wikeckowska A, et al.
Journal of Neurochemistry, 147(3), 361-379 (2018)
Faust's Anesthesiology Review E-Book (2014)
Method validation for simultaneous determination of atropine, pralidoxime and 12 organophosphorus compounds in blood samples by means of high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
<BIG>Marques GLM, et al</BIG>.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1097, 44-53 (2018)
Acute effects of drugs on C. elegans movement reveal complex responses and plasticity
Spensley MA, et al.
G3 (Bethesda, Md.), 299719-299719 (2018)
Laxmikant S Deshpande et al.
Toxicological sciences : an official journal of the Society of Toxicology, 116(2), 623-631 (2010-05-26)
Organophosphate (OP) compounds are among the most lethal chemical weapons ever developed and are irreversible inhibitors of acetylcholinesterase. Exposure to majority of OP produces status epilepticus (SE) and severe cholinergic symptoms that if left untreated are fatal. Survivors of OP
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全球贸易项目编号

货号GTIN
A0257-5G04061833327203
A0257-25G04061833327197
A0257-10G04061833327180

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