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Merck
CN

A0606

Sigma-Aldrich

金硫代葡萄糖 水合物

≥96% (titration), PKCι-Par6 interaction inhibitor, powder

别名:

Solganal, Solganol, 金硫代葡萄糖

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关于此项目

经验公式(希尔记法):
C6H11AuO5S · xH2O
化学文摘社编号:
分子量:
392.18 (anhydrous basis)
EC 号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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产品名称

金硫代葡萄糖 水合物, ≥96% (titration)

质量水平

方案

≥96% (titration)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 5 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1

InChI key

SGVIEHTYEMEDRR-PKXGBZFFSA-M

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应用

硫代葡萄糖水合物已用于人细胞系中的氧化还原应激存活测定,并用于诱导小鼠肥胖表型。

生化/生理作用

强效PKCι-Par6交互效应抑制剂
最近发现,临床上用于治疗类风湿关节炎的金化合物金硫代葡萄糖是一种有效的PKCiota-Par6交互效应抑制剂,IC50约为1 μM。破坏该交互效应会破坏rac1信号通路,这是非小细胞肺癌转化生长所必需的。

特点和优势

该化合物是受体分类及信号转导手册上PKC页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hiroshi Karasawa et al.
Obesity (Silver Spring, Md.), 19(3), 514-521 (2010-08-14)
An obesity-induced diabetes model using genetically normal mouse strains would be invaluable but remains to be established. One reason is that several normal mouse strains are resistant to high-fat diet-induced obesity. In the present study, we show the effectiveness of
Fumiko Isoda et al.
Brain research, 993(1-2), 172-176 (2003-12-04)
D-chiro-Inositol (DCI) enhances reproductive function in insulin-resistant women with polycystic ovarian disease and enhances the effects of insulin in the periphery, suggesting that this compound may act in part by sensitizing the hypothalamus to effects of insulin. Effects of gold-thioglucose
P Huypens et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 38(8), 486-490 (2006-08-31)
Following the chemically-induced lesion of the ventromedial nucleus, gold-thioglucose treated rodents display hypothalamic leptin resistance, hyperphagia, hyperinsulinemia and obesity. Despite the exuberant hyperinsulinemia following gold-thioglucose treatment, systemic insulin sensitivity is preserved during the early phase of the obesity syndrome, resulting
Eric N van Roon et al.
The Journal of rheumatology, 32(6), 1026-1030 (2005-06-09)
For reasons of insufficient quality of the raw material, aurothioglucose was withdrawn from the Dutch market at the end of 2001. Aurothiomalate became available as an alternative preparation. We followed a cohort of patients during the first year after switching
Kouichi Yoshinari et al.
Pharmaceutical research, 23(6), 1188-1200 (2006-05-23)
Changes in physiological, pathophysiological, and/or nutritional conditions often alter the expression of drug-metabolizing enzymes. In this study, we investigated obesity-induced changes in hepatic cytochrome P450 (P450) levels using nutritionally obese mice. To induce obesity, mice were fed a high-fat diet

商品

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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