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Merck
CN

A0606

金硫代葡萄糖 水合物

≥96% (titration), PKCι-Par6 interaction inhibitor, powder

别名:

Solganal, Solganol, 金硫代葡萄糖

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关于此项目

经验公式(希尔记法):
C6H11AuO5S · xH2O
化学文摘社编号:
分子量:
392.18 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
EC Number:
235-365-7
Assay:
≥96% (titration)
Form:
powder
Quality level:
Storage condition:
desiccated
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产品名称

金硫代葡萄糖 水合物, ≥96% (titration)

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1

InChI key

SGVIEHTYEMEDRR-PKXGBZFFSA-M

SMILES string

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

assay

≥96% (titration)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

Quality Level

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Application

硫代葡萄糖水合物已用于人细胞系中的氧化还原应激存活测定,并用于诱导小鼠肥胖表型。

Biochem/physiol Actions

强效PKCι-Par6交互效应抑制剂
最近发现,临床上用于治疗类风湿关节炎的金化合物金硫代葡萄糖是一种有效的PKCiota-Par6交互效应抑制剂,IC50约为1 μM。破坏该交互效应会破坏rac1信号通路,这是非小细胞肺癌转化生长所必需的。

Features and Benefits

该化合物是受体分类及信号转导手册上PKC页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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K D Anderson et al.
Journal of neuroendocrinology, 15(7), 649-660 (2003-06-06)
Similar to leptin, ciliary neurotrophic factor (CNTF) suppresses appetite and selectively reduces body fat in leptin-deficient ob/ob mice. To assess the relative importance of specific regions of the hypothalamus in mediating these effects, we administered a CNTF analogue (CNTFAx15) or
Melody Stallings-Mann et al.
Cancer research, 66(3), 1767-1774 (2006-02-03)
We recently showed that atypical protein kinase Ciota (PKCiota) is required for transformed growth of human non-small-cell lung cancer (NSCLC) cells by activating Rac1. Genetic disruption of PKCiota signaling blocks Rac1 activity and transformed growth, indicating that PKCiota is a
Satoru Sakuma et al.
Life sciences, 75(10), 1211-1218 (2004-06-29)
Effects of auranofin (AUR), aurothioglucose (AuTG) and aurothiomalate (AuTM) on the conversion of xanthine dehydrogenase (XD) to oxidase (XO) in the cytosolic fraction from rabbit liver were examined. AUR had no effect on the conversion of XD to XO at
Gabriela Maggioli et al.
The Journal of parasitology, 90(2), 205-211 (2004-05-29)
Thioredoxin reductase (TrxR), an enzyme belonging to the flavoprotein family of pyridine nucleotide-disulfide oxidoreductases, was isolated from the deoxycholate-soluble extract of the common liver fluke, Fasciola hepatica. Purification to homogeneity of the 60-kDa enzyme from the adult worm was achieved
M D Levin et al.
The Netherlands journal of medicine, 61(6), 223-225 (2003-09-19)
Thrombocytopenia is a well-known side effect following intramuscular gold therapy in patients with rheumatoid arthritis. Thrombocytopenia may occur at any time and it can be irreversible and sometimes fatal despite cytotoxic or immunosuppressive therapy. We describe two patients who presented

商品

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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