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A0781

Aphidicolin from Nigrospora sphaerica

Name: Aphidicolin from <I>Nigrospora sphaerica</I>
Brand: SIGMA

≥98% (HPLC), DNA polymerase inhibitor, powder

别名:

APC

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₄O₄

化学文摘社编号:

38966-21-1

分子量:

338.48

NACRES:

NA.77

PubChem Substance ID:

57653817

UNSPSC Code:

12352200

MDL number:

MFCD00083214

Beilstein/REAXYS Number:

4689958

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

300

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产品名称

Aphidicolin from Nigrospora sphaerica, ≥98% (HPLC), powder

Quality Level

300

assay

≥98% (HPLC)

form

powder

optical activity

[α]27/D +12°, c = 1 in methanol(lit.)

color

white

mp

227-233 °C (lit.)

solubility

ethanol: 1 mg/mL (stable at least a week at 4°C.), DMSO: 10 mg/mL (stable at least six weeks at −20°C.), methanol: 10 mg/mL, H₂O: insoluble

antibiotic activity spectrum

neoplastics, viruses

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

[H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

InChI key

NOFOAYPPHIUXJR-APNQCZIXSA-N

Gene Information

human ... POLA1(5422), POLD1(5424), POLG(5428)

Biochem/physiol Actions

Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Disclaimer

Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Comprehensive analysis of alterations in gene expression along with neoplastic transformation in human cells provides valuable information about the molecular mechanisms underlying transformation. To further address these questions, we performed whole transcriptome analysis to the human mesenchymal stem cell line

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.

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Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells are impaired in several chronic diseases including

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Chlamydia trachomatis is a sexually transmitted obligate intracellular pathogen that causes inflammatory reactive arthritis, spondylitis, psoriasiform dermatitis, and conjunctivitis in some individuals after genital infection. The immunologic basis for this inflammatory response in susceptible hosts is poorly understood. As ZAP-70(W163C)

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全球贸易项目编号

货号	GTIN
A0781-5MG	04061833334409
A0781-10MG	04061833334393
A0781-1MG	04061838443175

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