A0788
3-氨基苯甲酰胺
≥99% (TLC), PARP inhibitor, powder
别名:
3-AB, 3-ABA
产品名称
3-氨基苯甲酰胺, ≥99% (TLC)
质量水平
方案
≥99% (TLC)
表单
powder
颜色
white to off-white
mp
115-116 °C (lit.)
溶解性
ethanol: 50 mg/mL, clear, light yellow
DMSO: soluble
H2O: soluble (may require gentle heating)
储存温度
room temp
SMILES字符串
NC(=O)c1cccc(N)c1
InChI
1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChI key
GSCPDZHWVNUUFI-UHFFFAOYSA-N
基因信息
mouse ... Parp1(11545)
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应用
3-氨基苯甲酰胺已用作多种实验研究中的多聚（ADP-核糖）聚合酶(PARP)抑制剂。
生化/生理作用
3-氨基苯甲酰胺可干扰电离辐射和几种烷基化试剂诱发的DNA链断裂损伤修复，导致细胞死亡、程序外DNA合成和修复复制增加。它可抑制核酶多聚（ADP-核糖）合成酶(PARS)的活性。3-氨基苯甲酰胺具有抵抗心肌再灌注损伤和局部炎症的保护作用。
特点和优势
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts
Morgan W and Cleaver J
Cancer Research, 43(7), 3104-3107 (1983)
Cheng Wang et al.
Nature communications, 10(1), 1203-1203 (2019-03-15)
Vascular calcification is highly prevalent in end-stage renal diseases and is predictive of cardiovascular events and mortality. Poly(ADP-ribose) polymerase 1 (PARP1) inhibition or deletion is vasoprotective in several disease models. Here we show that PARP activity is increased in radial
BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide
Beauchamp M, et al.
Gynecologic Oncology, 115(2), 193-198 (2009)
An improved nonisotopic test to screen a large series of new inhibitor molecules of poly (ADP-ribose) polymerase activity for therapeutic applications
Decker P, et al.
Clinical Cancer Research, 5(5), 1169-1172 (1999)
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase
Zingarelli B, et al.
Cardiovascular Research, 36(2), 205-215 (1997)
商品
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
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