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A0835

N-Acetyl-Asp-Glu-Val-Asp-al

Name: N-Acetyl-Asp-Glu-Val-Asp-al
Brand: SIGMA

≥95%, powder

别名:

Ac-DEVD-CHO

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₀N₄O₁₁

化学文摘社编号:

169332-60-9

分子量:

502.47

NACRES:

NA.32

PubChem Substance ID:

24890193

UNSPSC Code:

12352209

MDL number:

MFCD00671412

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属性

biological source

synthetic

Quality Level

100

assay

≥95%

form

powder

color

white

solubility

H₂O: 1 mg/mL

storage temp.

−20°C

SMILES string

[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)

InChI key

UMBVAPCONCILTL-UHFFFAOYSA-N

Gene Information

human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)

说明

General description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 是一种具有N端乙酰化和C端醛共轭的四肽。

Application

N-Acetyl-Asp-Glu-Val-Asp-al已在肌肉样品、平滑肌细胞和Jurkat T细胞中被用作半胱氨酸蛋白酶抑制剂。

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 可通过其半胱氨酸蛋白酶抑制剂的功能性有助于顿抑心肌的恢复。

IL-1β的可逆性抑制剂；转化酶（ICE）；通过凋亡蛋白（caspase 3）抑制聚（ADP-核糖）聚合酶的切割。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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