A0862
A-740003
≥98% (HPLC)
别名:
N-（1-{[（氰亚胺基）（5-喹啉氨基）甲基] 氨基 }-2,2-二甲基丙基）-2-（3,4-二甲氧基苯基）乙酰胺
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选择尺寸
关于此项目
经验公式（希尔记法）:
C26H30N6O3
化学文摘社编号:
分子量:
474.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
PUHSRMSFDASMAE-UHFFFAOYSA-N
SMILES string
COc1ccc(CC(=O)NC(N\C(Nc2cccc3ncccc23)=N\C#N)C(C)(C)C)cc1OC
InChI
1S/C26H30N6O3/c1-26(2,3)24(31-23(33)15-17-11-12-21(34-4)22(14-17)35-5)32-25(29-16-27)30-20-10-6-9-19-18(20)8-7-13-28-19/h6-14,24H,15H2,1-5H3,(H,31,33)(H2,29,30,32)
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 10 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
General description
A-740003 是一种高度仿射和选择性 P2X7 受体拮抗剂，最适合于放射性示踪剂进展，用于正电子发射断层扫描神经炎症成像。
Biochem/physiol Actions
A-740003 是一种选择性 P2X7 嘌呤受体拮抗剂。
Features and Benefits
该化合物的相关信息整理于受体分类和信号转导手册的 P2受体：P2X离子通道家族 页面。欲浏览其他手册页面，请 点击这里。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Pablo J Sáez et al.
PloS one, 8(8), e71361-e71361 (2013-08-27)
Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation. Moreover, increasing evidence suggests that neuroinflammation plays a pivotal role in the development of Niemann-Pick type C (NPC) disease, an
Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C] A-740003 as a novel tracer of neuroinflammation
Janssen B, et al.
Journal of Labelled Compounds & Radiopharmaceuticals, 57(8), 509-516 (2014)
Melissa Crabbé et al.
Frontiers in neuroscience, 13, 799-799 (2019-08-17)
The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson's disease (PD). Recently, P2X7 imaging has become possible with [11C]JNJ-(54173)717. We investigated P2X7 availability, in comparison with availability of
Zihao Li et al.
Frontiers in cell and developmental biology, 9, 695041-695041 (2021-07-06)
Moderate-intensity exercise can help delay the development of osteoarthritis (OA). Previous studies have shown that the purinergic receptor P2X ligand gated ion channel 7 (P2X7) is involved in OA development and progression. To investigate the effect of exercise on P2X7
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