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Merck
CN

A0911

Sigma-Aldrich

[Ile7]-血管紧张素 III 乙酸盐 水合物

≥95% (HPLC)

别名:

Arg-Val-Tyr-Ile-His-Pro-Ile

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关于此项目

经验公式（希尔记法）:
C43H68N12O9 · xC2H4O2 · yH2O
分子量:
897.08 (anhydrous free base basis)
MDL编号:
MFCD11045994
UNSPSC代码:
12352209
PubChem化学物质编号:
329770638
NACRES:
NA.26

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Product Name

[Ile7]-血管紧张素 III 乙酸盐 水合物, ≥95% (HPLC)

质量水平

200

方案

≥95% (HPLC)

表单

powder

颜色

white

储存温度

−20°C

SMILES字符串

O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)[C@@H](C)CC)C(O)=O

InChI

1S/C43H68N12O9.C2H4O2.H2O/c1-7-24(5)34(40(61)51-31(20-27-21-47-22-49-27)41(62)55-18-10-12-32(55)38(59)54-35(42(63)64)25(6)8-2)53-37(58)30(19-26-13-15-28(56)16-14-26)50-39(60)33(23(3)4)52-36(57)29(44)11-9-17-48-43(45)46;1-2(3)4;/h13-16,21-25,29-35,56H,7-12,17-20,44H2,1-6H3,(H,47,49)(H,50,60)(H,51,61)(H,52,57)(H,53,58)(H,54,59)(H,63,64)(H4,45,46,48);1H3,(H,3,4);1H2/t24-,25-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

InChI key

YXASJLHKVNKIRW-ZPJCNHGSSA-N

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相关类别

生化/生理作用

In [Ile7]-Angiotensin III (Ile7-AIII) the seventh amino acid of angiotensin III (phe) is replaced with isoleucine. [Ile7]-Angiotensin III (Ile7 AIII) is an angiotensin III (A III) receptor antagonist used to selectively block the action of Angiotensin III.
[Ile7]-Angiotensin III is (Ile7-Ang III) used as a peptide angiotensin receptor antagonist often in comparison with other Ang antagonists such as saralasin.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000430774
SLCP0827
SLCP0827
0000430774
048K5102

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K S Lin et al.
The American journal of physiology, 272(5 Pt 2), H2204-H2210 (1997-05-01)
We evaluated the role of endogenous angiotensin II and III (ANG II and ANG III) at the rostral nucleus reticularis ventrolateralis (NRVL) in the modulation of baroreceptor reflex (BRR) response and the subtype of angiotensin receptors involved in this process.
M L Papouchado et al.
Journal of autonomic pharmacology, 15(1), 1-8 (1995-02-01)
1. Effects of angiotensin III (A III) on 3H-noradrenaline (3H-NA) total, neuronal and non-neuronal uptake, 3H intracellular distribution and release were studied in vitro in the rat hypothalamus. 2. A III (1 microM) decreased total, neuronal and non-neuronal 3H-NA uptake
J Y Chan et al.
Regulatory peptides, 50(3), 247-257 (1994-03-17)
We evaluated possible modulation by angiotensin III (AIII) of the interactive effect of noxious stimuli and elevation in systemic arterial pressure on the responsiveness of neurons in the nucleus reticularis gigantocellularis (NRGC) of the medulla oblongata. Combined extracellular single-neuron recording
E L Bravo et al.
The Journal of clinical endocrinology and metabolism, 40(3), 530-533 (1975-03-01)
The vascular and steroidogenic responses to (1-Sarcosine, 8-Isoleucine)-, and to (1-Des (Aspartic acid), 8-Isoleucine) angiotensin II were compared in bilaterally nephrectomized, ACTH-suppressed dogs receiving constant infusions of angiotensin II. Aldosterone secretion rate was significantly inhibited by pretreatment with 200 ng/Kg/min
Michelle A Clark et al.
Neuropeptides, 45(5), 329-335 (2011-07-27)
Angiotensin (Ang) III is a biologically active metabolite of Ang II with similar effects and receptor binding properties as Ang II. Most Ang III studies delineate physiological effects of the peptide but, the intracellular pathways leading to the actions are
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