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Merck
CN

A1009

Albumin methylated from bovine serum

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UNSPSC Code:
12352202
eCl@ss:
42010201
NACRES:
NA.26
MDL number:
Biological source:
bovine
Form:
powder
Technique(s):
affinity chromatography: suitable, fractionation: suitable
Impurities:
≤10% water (Karl Fischer)
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biological source

bovine

form

powder

origin

USA origin

technique(s)

affinity chromatography: suitable, fractionation: suitable

impurities

≤10% water (Karl Fischer)

UniProt accession no.

storage temp.

2-8°C

Quality Level

Gene Information

bovine ... ALB(280717)

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Application

Albumin methylated from bovine serum (mBSA) has been used as a coating for immunoplates in enzyme-linked immunosorbent assay (ELISA) of anti-dsDNA IgG antibodies. It has also been used to induce arthritis in mice models.
As an affinity ligand on diatomaceous earth support (MAK chromatography), a medium for fractionation of different forms of DNA and for separating aminoacyl-tRNAs. Different modes of binding of double-stranded, denatured, and replicating forms of DNA account for the efficacy of the method.

Biochem/physiol Actions

Albumin is a major circulating component of the plasma and is a highly soluble multifunctional protein. It plays a role in several physiological and pharmacological processes. Albumin binds to metals, cholesterol, hormones, bile pigments, drugs, and fatty acids to facilitate their transport. It regulates osmotic pressure and distributes fluids between various compartments.

Preparation Note

Methyl ester of albumin prepared per Mandell, J.D. and Hershey, A.D., Anal. Biochem., 1, 66 (1960).

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Kaoru Yamagata et al.
Clinical and experimental rheumatology, 38(4), 670-679 (2019-11-07)
Although articular cartilage contributes to smooth joint motion, once damaged this functionality cannot be recovered. Activation of the IL-6/STAT3 signalling pathway contributes to chondrogenic differentiation of mesenchymal stem cells (MSCs), indicating a role for soluble IL-6R (sIL-6R) during chondrogenesis in
Fractionation of amino acyl-acceptor RNA on a methylated albumin column.
N SUEOKA et al.
Proceedings of the National Academy of Sciences of the United States of America, 48, 1454-1461 (1962-08-01)
Mohammad Haque et al.
Scientific reports, 6, 20588-20588 (2016-02-06)
Pluripotent stem cells (PSCs) have the potential to produce almost all of the cells in the body, including regulatory T cells (Tregs). However, the exact conditions required for the development of antigen (Ag)-specific Tregs from PSCs (i.e., PSC-Tregs) are not
Ayaka Sato et al.
Biological & pharmaceutical bulletin, 45(12), 1798-1804 (2022-12-01)
OX40, a member of the tumor necrosis factor (TNF) receptor superfamily, is induced on activated T cells. Membrane-bound OX40 ligand (OX40L) expressed by activated antigen-presenting cells induces OX40 signaling, which promotes T cell immunity. OX40 agonism would be a potential
Wim B van den Berg et al.
Methods in molecular medicine, 136, 243-253 (2007-11-07)
Antigen induced arthritis is a unilateral T-cell driven model caused by direct injection of an antigen into the knee joint of a FCA preimmunized animal. The chronicity is determined by antigen retention in avascular structures of the joint through charge

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