A111
Adenosine amine congener hydrate
solid, ≥98% (HPLC)
别名:
ADAC, N6-[4-[[[4-[[[(2-Aminoethyl)amino]carbonyl]methyl]-anilino]carbonyl]methyl]phenyl]adenosine hydrate
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关于此项目
经验公式（希尔记法）:
C28H32N8O6 · xH2O
化学文摘社编号:
分子量:
576.60 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
white
溶解性
0.1 M acetic acid: 12 mM
DMSO: soluble
SMILES字符串
O.NCCNC(=O)Cc1ccc(NC(=O)Cc2ccc(Nc3ncnc4n(cnc34)[C@@H]5O[C@H](CO)[C@@H](O)[C@H]5O)cc2)cc1
InChI
1S/C28H32N8O6.H2O/c29-9-10-30-21(38)11-16-1-5-18(6-2-16)34-22(39)12-17-3-7-19(8-4-17)35-26-23-27(32-14-31-26)36(15-33-23)28-25(41)24(40)20(13-37)42-28;/h1-8,14-15,20,24-25,28,37,40-41H,9-13,29H2,(H,30,38)(H,34,39)(H,31,32,35);1H2/t20-,24-,25-,28-;/m1./s1
InChI key
KPSYUNGHYKDIMQ-LWOJYUBXSA-N
基因信息
rat ... Adora1(29290)
生化/生理作用
Potent aqueous-soluble A1 adenosine receptor agonist.
特点和优势
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
免责声明
Photosensitive
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H W Suh et al.
Neuropeptides, 31(4), 339-344 (1997-08-01)
A previous study reported that beta-endorphin and morphine administered supraspinally produce antinociception by activating different descending pain inhibitory systems. The present study was designed to investigate the blocking effects of A1 or A2 adenosine receptors in the spinal cord on
E Balcells et al.
European journal of pharmacology, 210(1), 1-9 (1992-01-07)
The endothelium is relatively 'impermeable' to adenosine. In addition, infusion of adenosine deaminase and transient infusion of large size adenosine agonists (molecular weight 100 kD) which are confined to the intravascular space depress effects of endogenous adenosine and retain physiologic
Rafael Rubio et al.
American journal of physiology. Heart and circulatory physiology, 284(1), H204-H214 (2002-10-22)
In isolated guinea pig hearts saline perfused at constant flow, adenosine A(1), A(2A), and A(3) (A(x)) agonists covalently bound to a large polymer (Pol; 2,000 kDa) were intracoronarily administered, and three effects were studied: dromotropic, vascular and inotropic. The rank
U Adén et al.
European journal of pharmacology, 426(3), 185-192 (2001-08-31)
We examined if the adenosine A(1) receptor agonist adenosine amine congener (ADAC, 100 microg/kg i.p.) is neuroprotective in 7-day-old rats subjected to hypoxic ischemia. Brain damage, evaluated as weight deficit and gross morphology, was not affected by ADAC treatment. Nonetheless
Adenosine A1 receptor agonists as clinically viable agents for treatment of ischemic brain disorders.
N Bischofberger et al.
Annals of the New York Academy of Sciences, 825, 23-29 (1997-11-25)
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