A111
Adenosine amine congener hydrate
solid, ≥98% (HPLC)
别名:
ADAC, N6-[4-[[[4-[[[(2-Aminoethyl)amino]carbonyl]methyl]-anilino]carbonyl]methyl]phenyl]adenosine hydrate
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关于此项目
经验公式（希尔记法）:
C28H32N8O6 · xH2O
化学文摘社编号:
分子量:
576.60 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
protect from light
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
white
solubility
0.1 M acetic acid: 12 mM, DMSO: soluble
SMILES string
O.NCCNC(=O)Cc1ccc(NC(=O)Cc2ccc(Nc3ncnc4n(cnc34)[C@@H]5O[C@H](CO)[C@@H](O)[C@H]5O)cc2)cc1
InChI
1S/C28H32N8O6.H2O/c29-9-10-30-21(38)11-16-1-5-18(6-2-16)34-22(39)12-17-3-7-19(8-4-17)35-26-23-27(32-14-31-26)36(15-33-23)28-25(41)24(40)20(13-37)42-28;/h1-8,14-15,20,24-25,28,37,40-41H,9-13,29H2,(H,30,38)(H,34,39)(H,31,32,35);1H2/t20-,24-,25-,28-;/m1./s1
InChI key
KPSYUNGHYKDIMQ-LWOJYUBXSA-N
Gene Information
rat ... Adora1(29290)
Biochem/physiol Actions
Potent aqueous-soluble A1 adenosine receptor agonist.
Features and Benefits
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Photosensitive
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H W Suh et al.
Neuropeptides, 31(4), 339-344 (1997-08-01)
A previous study reported that beta-endorphin and morphine administered supraspinally produce antinociception by activating different descending pain inhibitory systems. The present study was designed to investigate the blocking effects of A1 or A2 adenosine receptors in the spinal cord on
Rafael Rubio et al.
American journal of physiology. Heart and circulatory physiology, 284(1), H204-H214 (2002-10-22)
In isolated guinea pig hearts saline perfused at constant flow, adenosine A(1), A(2A), and A(3) (A(x)) agonists covalently bound to a large polymer (Pol; 2,000 kDa) were intracoronarily administered, and three effects were studied: dromotropic, vascular and inotropic. The rank
E Balcells et al.
European journal of pharmacology, 210(1), 1-9 (1992-01-07)
The endothelium is relatively 'impermeable' to adenosine. In addition, infusion of adenosine deaminase and transient infusion of large size adenosine agonists (molecular weight 100 kD) which are confined to the intravascular space depress effects of endogenous adenosine and retain physiologic
U Adén et al.
European journal of pharmacology, 426(3), 185-192 (2001-08-31)
We examined if the adenosine A(1) receptor agonist adenosine amine congener (ADAC, 100 microg/kg i.p.) is neuroprotective in 7-day-old rats subjected to hypoxic ischemia. Brain damage, evaluated as weight deficit and gross morphology, was not affected by ADAC treatment. Nonetheless
Lindsea C Booth et al.
Clinical and experimental pharmacology & physiology, 35(11), 1316-1320 (2008-08-02)
1. Adenosine A(1) receptor activation is critical for endogenous neuroprotection from hypoxia-ischaemia, raising the possibility that treatment with A(1) receptor agonists may be an effective physiological protection strategy for vulnerable preterm infants. However, the A(1) receptor can mediate unwanted systemic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A111-5MG | 04061832079097 |
| A111-25MG | 04061832268927 |
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