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Merck
CN

A11100P

DMT-dA(bz) Pharmadite®

别名:

DMT-dA(bz)亚磷酸酰胺

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关于此项目

经验公式（希尔记法）:
C47H52N7O7P
化学文摘社编号:
98796-53-3
分子量:
857.93
NACRES:
NA.51
PubChem Substance ID:
329770659
UNSPSC Code:
41116107
MDL number:
MFCD00036314
Assay:
≥99.5% (reversed phase HPLC), >99.5% (31P-NMR)
Biological source:
non-animal source (no BSE/TSE risk)
Form:
powder or granules
Solubility:
soluble, clear
Storage temp.:
2-8°C

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InChI key

GGDNKEQZFSTIMJ-AKWFTNRHSA-N

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7

InChI

1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-27-13-26-48)61-40-28-42(53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)60-41(40)29-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1

biological source

non-animal source (no BSE/TSE risk)

type

for DNA synthesis

product line

Proligo Reagents

assay

≥99.5% (reversed phase HPLC), >99.5% (31P-NMR)

form

powder or granules

technique(s)

oligo synthesis: suitable

impurities

>= 170ppm, none detected (S/N <2.5), ≤0.1% single unspecified Imprity (reversed phase HPLC), ≤0.3% P(III) 100-169ppm (31P-NMR), ≤0.3% dA2 (reversed phase HPLC, DMT-dA(bz) cyanoethyl-H-posphonate), ≤0.3% dA3 (reversed phase HPLC, DMT-dA(bz) phosphoramidate), ≤0.30 wt. % water content (Karl Fischer), ≤0.5% P(V) -25-99ppm (31P-NMR), ≤3.0 wt. % residual solvent content

color

white to off-white

solubility

soluble, clear

suitability

conforms to structure for H-NMR, conforms to structure for LC-MS

nucleoside profile

base: deoxyadenosine
base protecting group: benzoyl
2' protecting group: none
5' protecting group: DMT
deprotection: standard

storage temp.

2-8°C

Quality Level

300

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General description

DMT-dA(bz) Pharmadite® is a Pharmadite® product line that represents a new class of standard protected DNA phosphoramidites that are designed with highly controlled impurity profiles and exceptional overall purity. Pharmadite phosphoramidites are characterized by their exceptional purity and well-defined impurity profile. In particular, they are essentially free from contaminants that interfere in coupling reactions, such as other nucleosidic or non-nucleosidic phosphoramidites (P(III)-contaminants). All remaining impurities in Pharmadite phosphopramidites, if present, are identified, characterized, and quantified. The impact of any such defined impurities on the synthesis of oligonucleotides is well understood and has been shown to be insignificant.

Application

Pharmadite products fulfill all requirements of starting materials for themanufacture of active pharmaceutical ingredients as defined in the EMEA "Note for guidance on the chemistry of the new active substance," making them suitable building blocks for oligonucleotide drugs.

Other Notes

Pharmadite phosphoramidites are manufactured in scales of up to multi-hundred kilos, under certified ISO 9001 quality systems.

Legal Information

Pharmadite is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
HMBK8207
HMBK7811
HMBK5764
HMBK5029
HMBK0441

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