推荐产品
类型
for DNA synthesis
质量水平
产品线
Proligo Reagents
检测方案
≥98% (31P-NMR)
≥98.0% (reversed phase HPLC)
形式
powder
技术
oligo synthesis: suitable
λ
conforms (UV/VIS Identity)
相容性
configured for ABI
核苷分析
base: deoxyadenosine
base protecting group: TAC
2' protecting group: none
5' protecting group: DMT
deprotection: fast
储存温度
-10 to -25°C
SMILES字符串
COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)COc5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
InChI
1S/C48H54N7O8P/c1-33(2)55(34(3)4)64(61-27-13-26-49)63-41-28-44(54-32-52-45-46(50-31-51-47(45)54)53-43(56)30-59-40-16-11-8-12-17-40)62-42(41)29-60-48(35-14-9-7-10-15-35,36-18-22-38(57-5)23-19-36)37-20-24-39(58-6)25-21-37/h7-12,14-25,31-34,41-42,44H,13,27-30H2,1-6H3,(H,50,51,53,56)/t41-,42+,44+,64?/m0/s1
InChI key
INUFZOANRLMUCW-SDNJGBRXSA-N
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一般描述
- Deprotection of the TAC group is ultra-fast: complete deprotection in concentrated ammonia occurs within 15 minutes at 55 °C or two hours atroom temperature
- Compatible with the AMA deprotection reagent (a mixture of ≥25%ammonia in water with 40% aqueous methylamine I/I, v/v)
- Highly soluble in acetonitrile. No need to add co-solvents such as dimethylformamide or methylene chloride
- Suitable for the synthesis of oligomers with base-labile units e.g., dyes and modifiers, because of less exposure to ammonia and the possibility ofroom temperature deprotection
- No change is required in the reagents commonly used for DNA synthesis,except that Proligo′s Fast Deprotection Cap A solution is used instead ofCap A solution
- The application of dA(tac) minimizes depurination and improves thequality of oligonucleotides
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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