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Merck
CN

A1164

偶氮丝氨酸

Hybri-Max, γ-irradiated, 50x, lyophilized powder, BioXtra, suitable for hybridoma

别名:

O-重氮乙酰基-L-丝氨酸

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关于此项目

经验公式(希尔记法):
C5H7N3O4
化学文摘社编号:
分子量:
173.13
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
204-061-6
Beilstein/REAXYS Number:
1726602
MDL number:
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InChI key

MZZGOOYMKKIOOX-VKHMYHEASA-N

InChI

1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1

SMILES string

N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O

grade

Hybri-Max

sterility

γ-irradiated

product line

BioXtra

form

lyophilized powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

storage temp.

−20°C

Quality Level

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General description

Chemical structure: amino acid derivatives

Application

For use in hybridoma cell culture applications as a myeloma selection agent. Used to study inhibition of formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.

Biochem/physiol Actions

Azaserine is an antibiotic, generated by Streptomyces fragilis. It is considered as a potential mutation inducing agent. It is known to promote pancreatic cancer and induces adenoma and carcinoma in vivo and in vitro. Azaserine also stimulates kidney and liver tumors in rats.

Preparation Note

10mL 无菌细胞培养基可复原一小瓶本品。储备液足以制备 500mL 培养基。最终工作浓度:5.7μM 偶氮丝氨酸。

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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The presence of gastrin and cholecystokinin-2 (CCK2) receptors in human preneoplastic and neoplastic gastrointestinal lesions suggests a role in cancer development. In addition to the growth-promoting action of gastrin, recently a role of the cholecystokinin-2/gastrin receptor (CCK2-R) modulating cellular morphology
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Although mouse oocytes and cleavage-stage embryos are unable to utilize glucose as a metabolic fuel, they have a specific requirement for a short exposure to glucose prior to compaction. The reason for this requirement has been unclear. In this study
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