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Merck
CN

A126

(±)-HA-966

别名:

(±)-3-氨基-1-羟基-2-吡咯烷酮

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经验公式(希尔记法):
C4H8N2O2
化学文摘社编号:
分子量:
116.12
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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SMILES string

NC1CCN(O)C1=O

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Melissa Nunnink et al.
Pharmacology, biochemistry, and behavior, 87(3), 321-330 (2007-06-15)
Conditioned taste aversion (CTA) is a form of associative learning in which the pairing of a taste with a toxin causes an animal to avoid the taste. NMDA receptor mediated neurotransmission has been implicated in CTA, but the role of
David L Walker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(6), 2343-2351 (2002-03-16)
NMDA receptor antagonists block conditioned fear extinction when injected systemically and also when infused directly into the amygdala. Here we evaluate the ability of D-cycloserine (DCS), a partial agonist at the strychnine-insensitive glycine-recognition site on the NMDA receptor complex, to
Luigi Cervo et al.
Psychopharmacology, 173(1-2), 124-131 (2004-01-09)
(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in
Frédéric Adam et al.
Neuropharmacology, 54(3), 588-596 (2008-01-08)
Using the C-fibre reflex as a nociceptive response elicited by a wide range of stimulus intensities in the rat, we recently reported that a single treatment with (+)-HA966, a glycine site-specific NMDA receptor antagonist: (1) potentiates morphine antinociception; and (2)
Bradford D Fischer et al.
The journal of pain : official journal of the American Pain Society, 6(7), 425-433 (2005-07-05)
Although N-methyl-D-aspartate (NMDA) receptor antagonists clearly attenuate the development of tolerance to the antinociceptive effects of opioids, it is not clear whether they also alter acute opioid-induced antinociception. The present study was designed to assess NMDA/opioid interactions in C57BL/6 mice

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