A1260
盐酸金刚烷胺 盐酸盐
≥98% (TLC), powder, NMDA receptor antagonist
别名:
1-氨基金刚烷 盐酸盐, 1-金刚烷胺 盐酸盐, NSC 83653, 三环[3.3.1.1 3,7 ] 癸烷-1-胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C10H17N · HCl
化学文摘社编号:
分子量:
187.71
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
211-560-2
MDL number:
Beilstein/REAXYS Number:
4198854
Form:
powder
Quality level:
产品名称
盐酸金刚烷胺 盐酸盐,
form
powder
Quality Level
solubility
H2O: 50 mg/mL, ethanol: soluble
originator
Endo
SMILES string
Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
InChI
1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI key
WOLHOYHSEKDWQH-SOVZANNPSA-N
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General description
盐酸金刚烷胺{三环-[3,3,1,1]- deean-l-胺盐酸盐是一种以盐酸金刚乙胺为类似物的药物。
Application
使用盐酸金刚烷胺：
- 测定其在缓解手术引起的认知障碍方面的有效性
- 预培养多能干细胞(MSC)并研究细胞内化途径
- 确定金刚烷减毒脓毒症是否会诱发神经炎症和学习记忆功能障碍
- 预培养原代培养大鼠牙髓干细胞(rDPSC)
- 确定内化途径
Biochem/physiol Actions
盐酸金刚烷胺在体内和体外均对流感病毒有效。它还可作为N-甲基-D-天冬氨酸(NMDA)型谷氨酸受体的拮抗剂。金刚烷胺在多巴胺的释放中起着重要的作用，用于阻止多巴胺的再摄取并阻断小胶质细胞激活和神经炎症。
多巴胺释放剂用于治疗帕金森综合征和药物引起的锥体外系反应。
Features and Benefits
该化合物是 ADME Tox research 的特色产品。单击此处可发现更多ADME Tox 产品。前往sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
signalword
Danger
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Product Information Sheet
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A1260-5G | 04061833342008 |
| A1260-100G | 04061833341988 |
| A1260-25G | 04061833341995 |
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