A138
Aminobenztropine
solid
别名:
3-(2′-Aminobenzhydryloxy)tropane, ABT
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关于此项目
经验公式（希尔记法）:
C21H26N2O
化学文摘社编号:
分子量:
322.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Aminobenztropine, solid
InChI
1S/C21H26N2O/c1-23-16-11-12-17(23)14-18(13-16)24-21(15-7-3-2-4-8-15)19-9-5-6-10-20(19)22/h2-10,16-18,21H,11-14,22H2,1H3
SMILES string
CN1C2CCC1CC(C2)OC(c3ccccc3)c4ccccc4N
InChI key
KZFDKINRISJFCO-UHFFFAOYSA-N
form
solid
color
white
solubility
0.1 M HCl: soluble
0.1 M NaOH: insoluble
DMSO: soluble
methanol: soluble
Quality Level
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
Biochem/physiol Actions
High affinity muscarinic ligand that has been used for affinity purification of muscarinic cholinergic receptors.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Takafumi Tomida et al.
The Journal of toxicological sciences, 42(5), 641-650 (2017-09-15)
The utility of HepaRG cells as an in vitro cell-based assay system for predicting drug-induced phospholipidosis (PLD) was investigated. In experiment 1, 10 PLD-positive compounds and 11 PLD-negative compounds were selected. HepaRG cells were treated with each compound for 48
K Haga et al.
The Journal of biological chemistry, 258(22), 13575-13579 (1983-11-25)
A novel compound, 3-(2'-aminobenzhydryloxy)-tropane (ABT), and an ABT-agarose gel were synthesized and used for the purification of solubilized muscarinic receptors. ABT had a high affinity with an apparent dissociation constant (Kd) of 7 nM for the muscarinic receptors solubilized from
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Although the pathophysiology of carbamazepine-induced idiosyncratic or hypersensitivity reactions is unclear, they are presumed to be immune mediated, involving a complex interaction between drug metabolism and activation of the immune system. Cell stress can be caused by reactive metabolites, and
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