A1520
α-Amylase Inhibitor
≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase), ≥1000 inhibitor U/mg protein (using human salivary α-amylase), lyophilized powder
产品名称
α-淀粉酶抑制剂 来源于小麦 （小麦种子）, Type I, lyophilized powder
biological source
Triticum estivum
type
Type I
form
lyophilized powder
specific activity
≥1000 inhibitor U/mg protein (using human salivary α-amylase), ≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase)
composition
Protein, 35-65% biuret
storage temp.
−20°C
Quality Level
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General description
α-淀粉酶是糖苷内切酶，属于糖基水解酶家族13 (1-3)。
Application
目前已经采用小麦（小麦种子）来源α-淀粉酶抑制剂确定其对唾液腺 (SG) 淀粉酶活性的影响。此外，这种抑制剂还被用来抑制粉虱提取物的活性。
Biochem/physiol Actions
α-淀粉酶可以水解α-(1,4)-D-糖苷键。其可参与淀粉和糖原分解。抑制这种酶的做法可用作龋齿、糖尿病、肥胖症和牙周疾病的治疗策略。
人唾液α-淀粉酶的竞争性抑制剂。KI = 2.9 nM，而KM为5.9 mM（按每摩尔α-1,4-连接的麦芽糖残基计算）。
Physical form
冻干粉，含如磷酸钠之类的缓冲盐。
Other Notes
25°C预孵育后，一单位抑制剂可使两单位α-淀粉酶(A0521)活性降低50％。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
A review of alpha-amylase inhibitors on weight loss and glycemic control in pathological state such as obesity and diabetes
Mahmood N
Comparative clinical pathology, 25(6), 1253-1264 (2016)
Demonstration and preliminary characterization of
-amylase in the sweetpotato whitefly, Bemisia
tabaci (Aleyrodidae: Homoptera)
Cohen AC and Hendrix DL
Comparative Biochemistry and Physiology (1994)
Frauke Schocker et al.
International archives of allergy and immunology, 174(1), 17-25 (2017-09-28)
Little is known about breast milk as a vehicle for tolerance development or sensitization to peanuts very early in life. Thus, well-characterized and highly sensitive detection systems for the reliable determination of peanut allergens in breast milk are mandatory. For
alpha-Amylase inhibitors: a review of raw material and isolated compounds from plant source
Sales PM, et al.
J. Pharm. Pharm. Sci., 15(1), 141-183 (2012)
Partial characterization of alpha-amylase in the salivary glands of Lygus hesperus and L. lineolaris
Zeng F and Cohen AC
Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 126(1), 9-16 (2000)
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