A1527
Adrenocorticotropic Hormone Fragment 7-38 human
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C167H257N47O46
化学文摘社编号:
分子量:
3659.11
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥97% (HPLC)
biological source
synthetic (organic)
Quality Segment
sterility
non-sterile
assay
≥97% (HPLC)
form
powder
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... POMC(5443)
Application
Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.
Biochem/physiol Actions
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.
Other Notes
ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.
Lyophilized from 0.1% TFA in H2O
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)