A1527
Adrenocorticotropic Hormone Fragment 7-38 human
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C167H257N47O46
化学文摘社编号:
分子量:
3659.11
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥97% (HPLC)
biological source
synthetic (organic)
sterility
non-sterile
assay
≥97% (HPLC)
form
powder
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... POMC(5443)
Application
Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.
Biochem/physiol Actions
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.
Other Notes
ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.
Lyophilized from 0.1% TFA in H2O
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
C H Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 75(9), 4306-4309 (1978-09-01)
A corticotropin-inhibiting peptide (CIP) has been isolated from human pituitary extracts. It consists of 32 amino acids with a proposed sequence identical to residues 7--38 of corticotropin (ACTH). The peptide has been synthesized by the solid-phase method. The melanotropic activity
Min-Jung Kang et al.
Analytical and bioanalytical chemistry, 404(8), 2249-2258 (2012-09-04)
A multireaction monitoring method using high-performance liquid chromatography-tandem mass spectrometry was developed for 12 target peptides for determination of endogenous peptide concentrations in human serum. Chromatographic separation conditions were optimized and recoveries for liquid-liquid extraction, solid-phase extraction (SPE), and ultrafiltration
P Trindade et al.
Neuroscience letters, 487(1), 47-52 (2010-10-06)
The fine-tuning of topographically organized projections in sensory systems is strongly influenced by electrical activity and use-dependent modifications in synaptic strength. Since calcineurin (CaN), a Ca(2+)-calmodulin dependent serine/threonine phosphatase has been associated with activity-dependent modifications in synaptic efficacy we studied
G Mazzocchi et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 30(5), 241-243 (1998-07-11)
Vasoactive intestinal peptide (VIP) concentration-dependently enhanced corticosterone and cyclic-AMP release by dispersed rat inner adrenocortical cells. A VIP-receptor antagonist and the ACTH-receptor antagonist corticotropin-inhibiting peptide annulled both adrenocortical-cell responses to VIP, while the protein kinase (PKA) inhibitor H-89 blocked only
R Ekman et al.
Regulatory peptides, 8(4), 305-314 (1984-07-01)
Extracts of porcine anterior pituitary contain several corticotrophic variants of ACTH 1-39. They were isolated by adsorption chromatography, ion-exchange chromatography and reverse-phase high-performance liquid chromatography. Four variants were then identified as starting and ending at positions corresponding to ACTH 1-38
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