A155
反式-(±)-ACPD 一水合物
solid, ≥97% (NMR)
别名:
trans-(±)-1-Amino-1,3-cyclopentanedicarboxylic acid monohydrate
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关于此项目
经验公式（希尔记法）:
C7H11NO4 · H2O
化学文摘社编号:
分子量:
191.18
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C7H11NO4.H2O/c8-7(6(11)12)2-1-4(3-7)5(9)10;/h4H,1-3,8H2,(H,9,10)(H,11,12);1H2/t4-,7+;/m1./s1
SMILES string
O.N[C@]1(CC[C@H](C1)C(O)=O)C(O)=O
InChI key
AZRMVYVZWAKHMR-RERZVJIGSA-N
assay
≥97% (NMR)
form
solid
color
white
solubility
H2O: 1 mg/mL
Quality Level
Gene Information
human ... GRM1(2911), GRM2(2912), GRM3(2913), GRM4(2914), GRM5(2915), GRM6(2916), GRM7(2917), GRM8(2918)
Biochem/physiol Actions
Excitatory amino acid receptor agonist; selective for the metabotropic glutamate receptor subtype.
Other Notes
Note: under IUPAC nomenclature, this compound is designated cis.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.
E Palmer et al.
European journal of pharmacology, 166(3), 585-587 (1989-08-03)
D D Schoepp et al.
Journal of neurochemistry, 56(5), 1789-1796 (1991-05-01)
This study explored further the function of the metabotropic excitatory amino acid receptor in the rat brain. The trans and cis isomers of (+-)-1-amino-1,3-cyclopentane-dicarboxylic acid (ACPD) were characterized for relative affinities at ionotropic and metabotropic excitatory amino acid receptors in
Tzu-Chieh Chen et al.
Science signaling, 10(489) (2017-07-27)
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein angiopoietin-like 4, which mediates glucocorticoid-induced lipolysis in white adipose
P M Hwang et al.
Science (New York, N.Y.), 249(4970), 802-804 (1990-08-17)
With [3H]cytidine as a precursor, phosphoinositide turnover can be localized in brain slices by selective autoradiography of the product [3H]cytidine diphosphate diacylglycerol, which is membrane-bound. In the cerebellum, glutamatergic stimulation elicits an increase of phosphoinositide turnover only in Purkinje cells
Matthew E Larkum et al.
Journal of neurophysiology, 99(2), 683-694 (2007-11-30)
The six-layered mammalian neocortex evolved from the three-layered paleocortex, which is retained in present-day reptiles such as the turtle. Thus the turtle offers an opportunity to examine which cellular and circuit properties are fundamental to cortical function. We characterized the
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