A155
反式-(±)-ACPD 一水合物
solid, ≥97% (NMR)
别名:
trans-(±)-1-Amino-1,3-cyclopentanedicarboxylic acid monohydrate
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关于此项目
经验公式（希尔记法）:
C7H11NO4 · H2O
化学文摘社编号:
分子量:
191.18
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
反式-(±)-ACPD 一水合物, solid, ≥97% (NMR)
InChI
1S/C7H11NO4.H2O/c8-7(6(11)12)2-1-4(3-7)5(9)10;/h4H,1-3,8H2,(H,9,10)(H,11,12);1H2/t4-,7+;/m1./s1
SMILES string
O.N[C@]1(CC[C@H](C1)C(O)=O)C(O)=O
InChI key
AZRMVYVZWAKHMR-RERZVJIGSA-N
assay
≥97% (NMR)
form
solid
color
white
solubility
H2O: 1 mg/mL
Quality Level
Gene Information
human ... GRM1(2911), GRM2(2912), GRM3(2913), GRM4(2914), GRM5(2915), GRM6(2916), GRM7(2917), GRM8(2918)
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Biochem/physiol Actions
Excitatory amino acid receptor agonist; selective for the metabotropic glutamate receptor subtype.
Other Notes
Note: under IUPAC nomenclature, this compound is designated cis.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
P M Hwang et al.
Science (New York, N.Y.), 249(4970), 802-804 (1990-08-17)
With [3H]cytidine as a precursor, phosphoinositide turnover can be localized in brain slices by selective autoradiography of the product [3H]cytidine diphosphate diacylglycerol, which is membrane-bound. In the cerebellum, glutamatergic stimulation elicits an increase of phosphoinositide turnover only in Purkinje cells
D D Schoepp et al.
Journal of neurochemistry, 56(5), 1789-1796 (1991-05-01)
This study explored further the function of the metabotropic excitatory amino acid receptor in the rat brain. The trans and cis isomers of (+-)-1-amino-1,3-cyclopentane-dicarboxylic acid (ACPD) were characterized for relative affinities at ionotropic and metabotropic excitatory amino acid receptors in
Tzu-Chieh Chen et al.
Science signaling, 10(489) (2017-07-27)
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein angiopoietin-like 4, which mediates glucocorticoid-induced lipolysis in white adipose
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.
E Palmer et al.
European journal of pharmacology, 166(3), 585-587 (1989-08-03)
Shilpa P Rao et al.
Glia, 55(16), 1680-1689 (2007-09-22)
Astrocytes are now recognized as dynamic signaling elements in the brain. Bidirectional communication between neurons and astrocytes involves integration of neuronal inputs by astrocytes and release of gliotransmitters that modulate neuronal excitability and synaptic transmission. The ovarian steroid hormone, 17beta-estradiol
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