A166
阿达木单抗溶液 三乙铵盐 水合物
≥98% (HPLC), solid
别名:
Sp-Cyclic 3′,5′-hydrogen phosphorothioate adenosine hydrate, Sp-cAMPS triethylammonium salt
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关于此项目
经验公式（希尔记法）:
C10H11N5O5PS · C6H16N · xH2O
化学文摘社编号:
分子量:
446.46 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
产品名称
阿达木单抗溶液 三乙铵盐 水合物, ≥98% (HPLC), solid
InChI
1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21+;/m1./s1
SMILES string
CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@@](S)(=O)O[C@H]4[C@H]3O
InChI key
OXIPZMKSNMRTIV-BIQAKYJPSA-N
assay
≥98% (HPLC)
form
solid
optical activity
[α]22/D −25.43°, c = 0.99 in H2O(lit.)
color
white
solubility
H2O: soluble
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
A potent, membrane-permeable activator of cAMP-dependent protein kinase I and II.
Sp-Diastereomer of adenosine 3′,5′-cyclic monophosphorothioate is a potent, membrane-permeable activator of cAMP dependent protein kinase I and II that mimics the effects of cAMP as a second messenger in numerous systems while being resistant to cyclic nucleotide phosphodiesterases; exhibits greater specificity and affinity than forskolin and cAMP analogs such as dibutyryl-cAMP.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
B Yusta et al.
Journal of neurochemistry, 51(6), 1808-1818 (1988-12-01)
We have compared the effects of forskolin, N6,2'-O-dibutyryladenosine 3':5'-cyclic monophosphate (dibutyryl cyclic AMP, Bt2-cAMP), and butyrate on several aspects of neuroblastoma cell physiology. The morphology of Neuro 2A cells was similar after incubation with forskolin and Bt2-cAMP, which caused extensive
H G Scholübbers et al.
European journal of biochemistry, 138(1), 101-109 (1984-01-02)
The ability of 24 systematically modified analogues of adenosine 3',5'-monophosphate (cAMP) to enhance the synthesis of beta-galactosidase in glucose-repressed Escherichia coli strains KNBL 1001 and cpd- Crookes has been investigated. The properties of the analogues in comparison with cAMP are
The Atypical MAP Kinase ErkB Transmits Distinct Chemotactic Signals through a Core Signaling Module.
John M E Nichols et al.
Developmental cell, 48(4), 491-505 (2019-01-08)
Signaling from chemoattractant receptors activates the cytoskeleton of crawling cells for chemotaxis. We show using phosphoproteomics that different chemoattractants cause phosphorylation of the same core set of around 80 proteins in Dictyostelium cells. Strikingly, the majority of these are phosphorylated
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