A1737
A922500
synthetic (organic), >95% (HPLC), Diacylglycerol acyltransferase inhibitor, powder
产品名称
A922500,
生物来源
synthetic (organic)
质量水平
方案
>95% (HPLC)
表单
powder
分子量
Mw 428.5
溶解性
DMSO: 10 mg/mL, clear, colorless to greenish-yellow
储存温度
−20°C
SMILES字符串
N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1
InChI
1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
InChI key
BOZRFEQDOFSZBV-DHIUTWEWSA-N
应用
A922500 已用于抑制上皮人乳腺癌细胞系（MDA-MB-231）、毛地黄皂苷透化的人癌细胞、人肌管和巨噬细胞中的二酰基甘油酰基转移酶（DGAT）。
生化/生理作用
二酰基甘油酰基转移酶（DGAT-1）抑制剂； IC50 7 至 24 nM
二酰基甘油酰基转移酶（DGAT）1 抑制剂 A922500 在 0.03、0.3 和 3 mg/kg 浓度下可有效降低啮齿动物的餐后血清甘油三酯水平。这些结果表明 A922500 可能有助于降低心血管疾病风险。
外形
A922500 以结晶固体形式提供。
制备说明
储备溶液可以通过将 A922500 溶解在所选溶剂中来制备。A922500 可溶于乙醇、DMSO 和二甲基甲酰胺（DMF）等有机溶剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis
Leiguez E, et al.
Mediators of Inflammation, 2018 (2018)
Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress
Jarc E, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863(3), 247-265 (2018)
A specific lipid metabolic profile is associated with the epithelial mesenchymal transition program
Giudetti AM, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(3), 344-357 (2019)
Increased triacylglycerol-Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid
Lovsletten NG, et al.
PLoS ONE, 13(11), e0208048-e0208048 (2018)
Andrew J King et al.
European journal of pharmacology, 637(1-3), 155-161 (2010-04-14)
Postprandial serum triglyceride concentrations have recently been identified as a major, independent risk factor for future cardiovascular events. As a result, postprandial hyperlipidemia has emerged as a potential therapeutic target. The purpose of this study was two-fold. Firstly, to describe
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