A1757
6-氮杂嘧啶
≥98%, powder
别名:
6-AU, 1,2,4-三嗪-3,5(2H,4H)-二酮, 3,5-二羟基-1,2,4-三嗪, 6-氮杂-2,4-二羟基嘧啶
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关于此项目
经验公式（希尔记法）:
C3H3N3O2
化学文摘社编号:
分子量:
113.07
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
207-318-0
MDL number:
Beilstein/REAXYS Number:
116472
Application
6-氮杂尿嘧啶已用作转录抑制剂，用于研究其对终止和多聚腺苷酸化蛋白(Tpa1)和Mag1缺失细胞的活力影响。它还已用作基础培养基中的乳清酸核苷-5′-单磷酸脱羧酶(OMP脱羧酶)抑制剂，用于测定OMP脱羧酶活性。
Biochem/physiol Actions
6-氮杂尿嘧啶(6-AU)是尿嘧啶的嘧啶类似物，具有抗肿瘤活性。它可用于去除细胞内的鸟苷三磷酸(GTP)和尿苷三磷酸(UTP)两种核苷酸混合物，从而抑制各种微生物生长。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Sittinan Chanarat et al.
Genes & development, 25(11), 1147-1158 (2011-05-18)
Different steps in gene expression are intimately linked. In Saccharomyces cerevisiae, the conserved TREX complex couples transcription to nuclear messenger RNA (mRNA) export. However, it is unknown how TREX is recruited to actively transcribed genes. Here, we show that the
methods in molecular biology
steroid receptor methods (2001)
Kostyantyn V Dmytruk et al.
Metabolic engineering, 13(1), 82-88 (2010-11-03)
Currently, the mutant of the flavinogenic yeast Candida famata dep8 isolated by classic mutagenesis and selection is used for industrial riboflavin production. Here we report on construction of a riboflavin overproducing strain of C. famata using a combination of random
Valérie Declerck et al.
The Journal of organic chemistry, 76(2), 708-711 (2010-12-25)
A short and efficient synthesis of the previously unknown N-aminoazetidinecarboxylic acid has been established using a photochemical [2 + 2] cycloaddition strategy starting from 6-azauracil. Chiral derivatization with a nonracemic oxazolidinone provided access to both enantiomers of the title product.
Mattias Carlsson et al.
PloS one, 13(5), e0196840-e0196840 (2018-05-09)
Purine and pyrimidine analogues have important uses in chemotherapies against cancer, and a better understanding of the mechanisms that cause resistance to these drugs is therefore of importance in cancer treatment. In the yeast Saccharomyces cerevisiae, overexpression of the HAM1
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